| Mechanosensory properties in the human gastric antrum evaluated using B-mode ultrasonography during volume-controlled antral distension. | |
| | |
MedLine Citation:
|
PMID: 16293656 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The aims of this study were to evaluate gastric antral mechanical behavior and distension-induced sensorimotor responses in the human gastric antrum using transabdominal ultrasound scanning. Ten healthy volunteers underwent volume-controlled ramp inflation of a bag located in the antrum with volumes up to 125 ml. The active and passive circumferential tensions and stresses were calculated from measurements of pressure, diameter, and wall thickness before and during the administration of the anticholinergic drug butylscopolamine. The bag distensions elicited contractions in the antrum and sensory responses below the pain threshold. Butylscopolamine abolished the contractions and significantly reduced the sensory response. The length-tension diagram known from in vitro studies of smooth muscle strips could be reproduced as tension-volume diagrams in the human gastric antrum. The number of induced contractions and the contraction pressure amplitude (afterload) showed a parabolic behavior as function of the distension volume (preload), with maximum approximately at 70 ml. At the sensation threshold, the luminal circumference showed the lowest variation coefficient (13-25%), whereas the variation coefficient was more than 100% for the pressure, tensions, and stresses. We conclude that the muscle length-tension diagram and typical preload-afterload curves ad modem the Frank-Starling cardiac law can be obtained in the human gastric antrum. The sensory responses were most closely associated with the luminal circumference, indicating that the sensation during antral distension depends on deformation rather than on tension. |
| | |
Authors:
|
H Gregersen; T Hausken; J Yang; S Ødegaard; O H Gilja |
Related Documents
:
|
12224376 - Effects of ecabet sodium, an antiulcer drug, on gastric adaptive relaxation in isolated... 18350336 - Effects of caffeine on anorectal manometric findings. 8074216 - Relaxation responses of the human proximal stomach to distension during fasting and aft... 18269646 - Manometric study of the lower esophageal sphincter and esophagus in subtotal gastrectom... 7140016 - Pressure-induced changes in coronary flow and volume during reperfusion in canine hearts. 22008026 - Epicardial fat thickness is associated with non-dipper blood pressure pattern in patien... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2005-11-17 |
Journal Detail:
|
Title: American journal of physiology. Gastrointestinal and liver physiology Volume: 290 ISSN: 0193-1857 ISO Abbreviation: Am. J. Physiol. Gastrointest. Liver Physiol. Publication Date: 2006 May |
Date Detail:
|
Created Date: 2006-04-10 Completed Date: 2006-07-13 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 100901227 Medline TA: Am J Physiol Gastrointest Liver Physiol Country: United States |
Other Details:
|
Languages: eng Pagination: G876-82 Citation Subset: IM |
Affiliation:
|
Center for Visceral Biomechanics and Pain, Aalborg Hospital, Hobrovej 42A, DK-9100 Aalborg, Denmark. hag@smi.auc.dk |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Butylscopolammonium Bromide / pharmacology Dilatation Female Gastrointestinal Motility / physiology Humans Male Middle Aged Muscle Contraction / physiology* Peristalsis / drug effects, physiology Pressure Pyloric Antrum / physiology*, ultrasonography* Sensation Stress, Mechanical |
| Chemical | |
Reg. No./Substance:
|
149-64-4/Butylscopolammonium Bromide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Spontaneous electrical rhythmicity and the role of the sarcoplasmic reticulum in the excitability of...
Next Document: Differential cytokine response from dendritic cells to commensal and pathogenic bacteria in differen...