Document Detail

Mechanoreceptors of the proximal stomach: Role in triggering transient lower esophageal sphincter relaxation.
MedLine Citation:
PMID:  14699486     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND AIMS: The role of fundic tension and stretch mechanoreceptors in triggering transient lower esophageal sphincter (LES) relaxation is still unknown. This information would be useful for the development of effective pharmacologic strategies. To elucidate this topic, gastric contractile activity was modified during isovolumetric gastric distention at 2 different volumes. METHODS: LES (Dentsleeve) and gastric (barostat) motility were recorded in 21 healthy subjects during studies comprising two 30-minute isovolumetric gastric distentions (placebo and glucagon or erythromycin). Glucagon (bolus of 4.8 microg/kg plus infusion of 9.6 microg x kg(-1) x h(-1)) was administered at high intragastric volume (i.e., 75% of the threshold volume for discomfort; n = 7) and erythromycin (3 mg/kg) at high (n = 7) and low intragastric volume (i.e., at perception threshold; n = 7). RESULTS: Glucagon decreased (P < 0.05) baseline intragastric pressure and abolished gastric contractions (0 vs. 16.7 +/- 2.3), whereas erythromycin increased (P < 0.05) baseline pressure and doubled (P < 0.05) the rate of gastric contractions at both volumes. Neither drug affected the rate of transient LES relaxations. Low intragastric volume induced a lower rate of transient LES relaxations (1.7 +/- 0.3 vs. 5.7 +/- 1.1; P < 0.01) and gastric contractions (11.8 +/- 2.5 vs. 20.5 +/- 3.1; P < 0.05) compared with high volume but similar baseline intragastric pressure (10.6 +/- 0.6 vs. 11.9 +/- 0.9 mm Hg). CONCLUSIONS: Stretch receptors (gastric volume) seem to be more relevant than tension receptors in triggering transient LES relaxation.
Roberto Penagini; Stefania Carmagnola; Paolo Cantù; Mariangela Allocca; Paolo A Bianchi
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Gastroenterology     Volume:  126     ISSN:  0016-5085     ISO Abbreviation:  Gastroenterology     Publication Date:  2004 Jan 
Date Detail:
Created Date:  2003-12-30     Completed Date:  2004-02-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0374630     Medline TA:  Gastroenterology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  49-56     Citation Subset:  AIM; IM    
Cattedra di Gastroenterologia, Dipartimento di Scienze Mediche, University of Milan, Italy.
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MeSH Terms
Blood Glucose / analysis
Erythromycin / pharmacology
Esophagogastric Junction / physiology*
Gastrointestinal Agents / pharmacology
Gastrointestinal Motility / drug effects
Glucagon / pharmacology
Mechanoreceptors / physiology*
Muscle Relaxation / physiology*
Stomach / innervation*,  physiology*
Reg. No./Substance:
0/Blood Glucose; 0/Gastrointestinal Agents; 114-07-8/Erythromycin; 9007-92-5/Glucagon

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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