| Mechanoelectrical coupling enhances initiation and affects perpetuation of atrial fibrillation during acute atrial dilation. | |
| | |
MedLine Citation:
|
PMID: 21075218 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
BACKGROUND: Acute atrial dilation increases the susceptibility to atrial fibrillation (AF). However, the mechanisms by which atrial stretch may contribute to the initiation and perpetuation of AF remain to be determined. OBJECTIVE: The purpose of this study was use a novel multiscale model of atrial electromechanics and mechanoelectrical feedback to test the hypothesis of whether acute stretch increases vulnerability to AF by heterogeneous activation of stretch-activated channels. METHODS: Human atria were represented by a triangular mesh obtained from magnetic resonance imaging data. Atrial trabecular bundle structure was incorporated by varying thicknesses of the atrial wall. Atrial membrane behavior was modeled by the Courtemanche-Ramirez-Nattel model with the addition of a nonselective stretch-activated cation current (I(sac)). Mechanical behavior was modeled by a series elastic, a contractile, and a parallel elastic element in which contractile force was related to intracellular concentration of free calcium and sarcomere length. RESULTS: Acute atrial dilation was simulated by increasing stretch throughout the atrial wall. Stimulation near the pulmonary vein ostia at an interval of 600 ms induced AF at an overall stretch ratio of 1.10. Initiation and perpetuation of AF in our model were related to increased dispersion of effective refractory period, conduction slowing, and local conduction block, all related to heterogeneous activation of I(sac). Upon local contraction, mechanoelectrical coupling affects perpetuation of AF by temporarily changing local excitability. CONCLUSION: During acute atrial dilation, heterogeneous activation of I(sac) enhances initiation and can affect perpetuation of AF. |
| | |
Authors:
|
Nico H L Kuijpers; Mark Potse; Peter M van Dam; Huub M M Ten Eikelder; Sander Verheule; Frits W Prinzen; Ulrich Schotten |
Related Documents
:
|
12834568 - Surgical remodeling in ischemic cardiomyopathy. 20516518 - Traversing and dilating venous collaterals: a useful adjunct in left ventricular electr... 21423368 - Alternans in genetically modified langendorff-perfused murine hearts modeling catechola... 21311678 - Metformin inhibits isoproterenol-induced cardiac hypertrophy in mice. 22607158 - Intra-aortic balloon counterpulsation in the treatment of infarction-related cardiogeni... 17433988 - Atrioventricular canal: modified single patch technique. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2010-11-12 |
Journal Detail:
|
Title: Heart rhythm : the official journal of the Heart Rhythm Society Volume: - ISSN: 1556-3871 ISO Abbreviation: - Publication Date: 2010 Nov |
Date Detail:
|
Created Date: 2011-1-26 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101200317 Medline TA: Heart Rhythm Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2011 Heart Rhythm Society. Published by Elsevier Inc. All rights reserved. |
Affiliation:
|
Department of Biomedical Engineering, Maastricht University, Maastricht, The Netherlands. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Morphologic pattern of the intrinsic ganglionated nerve plexus in mouse heart.
Next Document: Strong genetic structure in Cameroonian populations of Bulinus truncatus (Gastropoda: Planorbidae), ...