Document Detail


Mechanobiology of tendon adaptation to compressive loading through fibrocartilaginous metaplasia.
MedLine Citation:
PMID:  10850819     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Tendons that wrap around bones often undergo fibrocartilaginous metaplasia. In this paper, we examine the biomechanical causes and consequences of this metaplasia. We propose an adaptation rule in which tissue permeability changes in response to local cyclic hydrostatic pressures associated with physical activity. The proposed rule predicts the development of a low-permeability region corresponding to the fibrocartilaginous region in a representative wrap-around tendon. A poroelastic finite element model is used to examine the time-dependent fluid pressures and compressive stresses and strains in the solid constituents of the tendon's extrafibrillar matrix. The low permeability in the adapted fibrocartilaginous region maintains fluid pressures, protecting the solid constituents of the tendon's extracellular matrix from high compressive stresses and strains that could disrupt the matrix organization. Adaptation through fibrocartilaginous metaplasia therefore allows wrap-around tendons to function effectively over a lifetime without sustaining excessive mechanical damage due to cyclic compressive loading.
Authors:
T A Wren; G S Beaupré; D R Carter
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Journal of rehabilitation research and development     Volume:  37     ISSN:  0748-7711     ISO Abbreviation:  J Rehabil Res Dev     Publication Date:    2000 Mar-Apr
Date Detail:
Created Date:  2000-09-26     Completed Date:  2000-09-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8410047     Medline TA:  J Rehabil Res Dev     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  135-43     Citation Subset:  IM; S    
Affiliation:
Rehabilitation Research & Development Center, Veterans Affairs Health Care System, Palo Alto, CA 94304, USA. wren@stanford.edu
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MeSH Terms
Descriptor/Qualifier:
Adaptation, Physiological / physiology
Animals
Biomechanics
Cartilage / pathology*,  physiology*
Models, Biological
Rabbits
Stress, Mechanical
Tendons / pathology*,  physiology*
Weight-Bearing*
Comments/Corrections
Comment In:
J Rehabil Res Dev. 2000 Sep-Oct;37(5):xvii-xix   [PMID:  11322163 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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