Document Detail


Mechanobiology: a new frontier for human pluripotent stem cells.
MedLine Citation:
PMID:  23337973     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Research on human pluripotent stem cells (hPSCs) has expanded rapidly over the last two decades, owing to the promises of hPSCs for applications in regenerative medicine, disease modeling, and developmental biology studies. While most studies of hPSCs have so far focused on identifying extrinsic soluble factors, intracellular signaling pathways, and transcriptional networks that are involved in regulating hPSC self-renewal and differentiation, a few promising studies have emerged in recent years to reveal some unique mechano-sensitive and -responsive properties of hPSCs and the effect of the physical aspects of the local cellular microenvironment on regulating hPSC behaviors. This Frontier Review is to highlight these recent studies of mechanobiology in hPSCs and to discuss the impact of advancing our understanding of mechanoregulation of hPSC behaviors on improving survival, self-renewal and differentiation of hPSCs using well-controlled synthetic micro/nanoscale cell culture tools.
Authors:
Yubing Sun; Jianping Fu
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review    
Journal Detail:
Title:  Integrative biology : quantitative biosciences from nano to macro     Volume:  5     ISSN:  1757-9708     ISO Abbreviation:  Integr Biol (Camb)     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-02-25     Completed Date:  2013-09-24     Revised Date:  2014-08-05    
Medline Journal Info:
Nlm Unique ID:  101478378     Medline TA:  Integr Biol (Camb)     Country:  England    
Other Details:
Languages:  eng     Pagination:  450-7     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Apoptosis
Cell Adhesion Molecules / metabolism
Cell Culture Techniques
Cell Differentiation / physiology
Cell Lineage
Extracellular Matrix
Humans
Pluripotent Stem Cells / cytology*
Stress, Mechanical
Grant Support
ID/Acronym/Agency:
P50 CA069568/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Cell Adhesion Molecules
Comments/Corrections

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