| Mechano-Responsive Hydrogels Crosslinked by Block Copolymer Micelles. | |
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MedLine Citation:
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PMID: 23024698 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Block copolymer micelles (BCMs) were prepared from amphiphilic diblock copolymers of poly(n-butyl acrylate) and poly(acrylic acid) partially modified with 2-hydroxyethyl acrylate. Radical polymerization of acrylamide in the presence of micellar crosslinkers gave rise to elastomeric hydrogels (BCM-PAAm) whose mechanical properties can be tuned by varying the BCM composition. Transmission electron microscopy (TEM) imaging revealed stretch-induced, reversible micelle deformation in BCM-PAAm gels. A model hydrophobic drug, pyrene, loaded into the micelle core prior to the formation of BCM-PAAm gels, was dynamically released in response to externally applied mechanical forces. The BCM-crosslinked hydrogels with combined strength and force-modulated drug release are attractive candidates for the repair and regeneration of mechanically-active tissues. |
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Authors:
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Longxi Xiao; Jiahua Zhu; David J Londono; Darrin J Pochan; Xinqiao Jia |
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Publication Detail:
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Type: JOURNAL ARTICLE |
Journal Detail:
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Title: Soft matter Volume: 8 ISSN: 1744-6848 ISO Abbreviation: Soft Matter Publication Date: 2012 Oct |
Date Detail:
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Created Date: 2012-10-1 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101295070 Medline TA: Soft Matter Country: - |
Other Details:
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Languages: ENG Pagination: 10233-10237 Citation Subset: - |
Affiliation:
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Department of Materials Science and Engineering, Delaware Biotechnology Institute, University of Delaware, Newark, DE 19716, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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