Document Detail


Mechano-Responsive Hydrogels Crosslinked by Block Copolymer Micelles.
MedLine Citation:
PMID:  23024698     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Block copolymer micelles (BCMs) were prepared from amphiphilic diblock copolymers of poly(n-butyl acrylate) and poly(acrylic acid) partially modified with 2-hydroxyethyl acrylate. Radical polymerization of acrylamide in the presence of micellar crosslinkers gave rise to elastomeric hydrogels (BCM-PAAm) whose mechanical properties can be tuned by varying the BCM composition. Transmission electron microscopy (TEM) imaging revealed stretch-induced, reversible micelle deformation in BCM-PAAm gels. A model hydrophobic drug, pyrene, loaded into the micelle core prior to the formation of BCM-PAAm gels, was dynamically released in response to externally applied mechanical forces. The BCM-crosslinked hydrogels with combined strength and force-modulated drug release are attractive candidates for the repair and regeneration of mechanically-active tissues.
Authors:
Longxi Xiao; Jiahua Zhu; David J Londono; Darrin J Pochan; Xinqiao Jia
Related Documents :
22486708 - Time-resolved indirect nanoplasmonic sensing spectroscopy of dye molecule interactions ...
24681378 - Star-shaped polymers of bio-inspired algae core and poly(acrylamide) and poly(acrylic a...
22886488 - Influence of maize flour particle size on gluten-free breadmaking.
22315998 - Conformation types of ubiquitin [m+8h]8+ ions from water:methanol solutions: evidence f...
5955798 - Growth of desulfovibrio on the surface of agar media.
21772068 - Free-standing zno-cuo composite nanowire array films and their gas sensing properties.
Publication Detail:
Type:  JOURNAL ARTICLE    
Journal Detail:
Title:  Soft matter     Volume:  8     ISSN:  1744-6848     ISO Abbreviation:  Soft Matter     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-1     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101295070     Medline TA:  Soft Matter     Country:  -    
Other Details:
Languages:  ENG     Pagination:  10233-10237     Citation Subset:  -    
Affiliation:
Department of Materials Science and Engineering, Delaware Biotechnology Institute, University of Delaware, Newark, DE 19716, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Mechanism by Sambucus nigra Extract Improves Bone Mineral Density in Experimental Diabetes.
Next Document:  Regulatory T cells and Th17 cells in viral infections: implications for multiple sclerosis and myoca...