Document Detail

Mechano-Responsive Hydrogels Crosslinked by Block Copolymer Micelles.
MedLine Citation:
PMID:  23024698     Owner:  NLM     Status:  Publisher    
Block copolymer micelles (BCMs) were prepared from amphiphilic diblock copolymers of poly(n-butyl acrylate) and poly(acrylic acid) partially modified with 2-hydroxyethyl acrylate. Radical polymerization of acrylamide in the presence of micellar crosslinkers gave rise to elastomeric hydrogels (BCM-PAAm) whose mechanical properties can be tuned by varying the BCM composition. Transmission electron microscopy (TEM) imaging revealed stretch-induced, reversible micelle deformation in BCM-PAAm gels. A model hydrophobic drug, pyrene, loaded into the micelle core prior to the formation of BCM-PAAm gels, was dynamically released in response to externally applied mechanical forces. The BCM-crosslinked hydrogels with combined strength and force-modulated drug release are attractive candidates for the repair and regeneration of mechanically-active tissues.
Longxi Xiao; Jiahua Zhu; David J Londono; Darrin J Pochan; Xinqiao Jia
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Publication Detail:
Journal Detail:
Title:  Soft matter     Volume:  8     ISSN:  1744-6848     ISO Abbreviation:  Soft Matter     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-1     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101295070     Medline TA:  Soft Matter     Country:  -    
Other Details:
Languages:  ENG     Pagination:  10233-10237     Citation Subset:  -    
Department of Materials Science and Engineering, Delaware Biotechnology Institute, University of Delaware, Newark, DE 19716, USA.
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