| Mechanistic study of the effect of roller compaction and lubricant on tablet mechanical strength. | |
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MedLine Citation:
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PMID: 17455360 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Heckel analysis, tablet tensile strength, and indentation hardness were determined for a series of sieved and roller compacted microcrystalline cellulose mixtures under both unlubricated and lubricated conditions with magnesium stearate. These results have been used to evaluate the loss of reworkability following roller compaction for microcrystalline cellulose and show the extent of impact on tableting properties when magnesium stearate is added intragranularly prior to roller compaction. While results consistent with traditional work-hardening are observed as shown by a modest increase in dynamic hardness and mean yield pressure for unlubricated, roller compacted microcrystalline cellulose, it is overshadowed by the overlubrication effect seen during roller compaction and in particular, the subsequent milling step. The common practice of lubricating the feedstock with magnesium stearate to avoid sticking of the material to the compaction rolls appears to be the major cause of decreased mechanical strength of the final compressed tablets. |
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Authors:
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Xiaorong He; Pamela J Secreast; Gregory E Amidon |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of pharmaceutical sciences Volume: 96 ISSN: 0022-3549 ISO Abbreviation: J Pharm Sci Publication Date: 2007 May |
Date Detail:
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Created Date: 2007-04-30 Completed Date: 2007-06-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 2985195R Medline TA: J Pharm Sci Country: United States |
Other Details:
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Languages: eng Pagination: 1342-55 Citation Subset: IM |
Copyright Information:
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(c) 2007 Wiley-Liss, Inc. and the American Pharmacists Association. |
Affiliation:
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Pfizer, Inc, Ann Arbor, Michigan, USA. xiaorong.x.he@gsk.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cellulose
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chemistry* Chemistry, Pharmaceutical Compressive Strength Drug Compounding Excipients / chemistry* Hardness Lubrication Models, Chemical Stearic Acids / chemistry* Tablets Technology, Pharmaceutical / methods* Tensile Strength |
| Chemical | |
Reg. No./Substance:
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0/Excipients; 0/Stearic Acids; 0/Tablets; 0/microcrystalline cellulose; 57-11-4/stearic acid; 9004-34-6/Cellulose |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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