Document Detail

Mechanistic studies of fluorescent sensors for the detection of reactive oxygen species.
MedLine Citation:
PMID:  18175005     Owner:  NLM     Status:  MEDLINE    
Two new sensors for the detection of reactive oxygen species have been synthesized and characterized; they contain the 4-amino-7-nitrobenzofurazan (ABF) moiety covalently tethered to a phenol. Comparison of sensors ABFhd and dABFhd (the latter containing two ortho-methyl groups) shows that introduction of steric bulk leads to an improvement of fluorescent sensor performance, thus confirming our previous predictions based on computational chemistry. ABFhd and dABFhd are new tools for biological applications involving reactive oxygen species, in particular oxygen-centered radicals.
Belinda Heyne; Sara Ahmed; J C Scaiano
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-12-03
Journal Detail:
Title:  Organic & biomolecular chemistry     Volume:  6     ISSN:  1477-0520     ISO Abbreviation:  Org. Biomol. Chem.     Publication Date:  2008 Jan 
Date Detail:
Created Date:  2008-01-04     Completed Date:  2008-04-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101154995     Medline TA:  Org Biomol Chem     Country:  England    
Other Details:
Languages:  eng     Pagination:  354-8     Citation Subset:  IM    
University of Ottawa, Department of Chemistry, 10 Marie Curie, Ottawa, ON K1N 6N5, Canada.
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MeSH Terms
Benzoxazoles / chemistry
Fluorescent Dyes / chemical synthesis,  chemistry*
Molecular Structure
Reactive Oxygen Species / analysis*
Sensitivity and Specificity
Spectrometry, Fluorescence / methods
Spectrophotometry, Ultraviolet / methods
Time Factors
Reg. No./Substance:
0/4-amino-7-nitrobenzofurazan; 0/Benzoxazoles; 0/Fluorescent Dyes; 0/Reactive Oxygen Species

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