Document Detail

Mechanistic insights into initiation and maintenance of ventricular fibrillation: implications for catheter ablation.
MedLine Citation:
PMID:  20306885     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: This report is intended to provide an overview of the mechanism(s) of ventricular fibrillation (VF) and its relation to catheter ablation. METHODS AND RESULT: We conducted a Pubmed and Medline literature search to identify all experimental and clinical studies published in English involving the mechanisms of VF and catheter ablation for VF. We found that controversies still exist with respect to the initiation and maintenance of VF despite more than a century of research due to the complexity of this arrhythmia and the limitation of the mapping technology. However, catheter ablation targeting the triggering factor for VF has been successfully applied in some patients who experience failure of drug therapy and frequent implanted cardiac defibrillator shocks. CONCLUSIONS: VF is frequently triggered by short-coupled monophasic ventricular premature beats. VF is characteristic of partial and temporal organization instead of a state of completely aperiodic and disordered activation. Catheter ablation targeting the triggers for VF seems to be a safe and effective means for preventing VF in some patients.
Zhibing Lu; Sunny S Po; Hong Jiang
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Acta cardiologica     Volume:  65     ISSN:  0001-5385     ISO Abbreviation:  Acta Cardiol     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-03-23     Completed Date:  2010-04-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370570     Medline TA:  Acta Cardiol     Country:  Belgium    
Other Details:
Languages:  eng     Pagination:  15-22     Citation Subset:  IM    
Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China.
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MeSH Terms
Catheter Ablation / methods*
Heart Conduction System / physiopathology*,  surgery
Heart Rate / physiology*
Ventricular Fibrillation* / diagnosis,  physiopathology,  surgery

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