| Mechanistic electronic model to simulate and predict the effect of heat stress on the functional genomics of HO-1 system: Vasodilation. | |
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MedLine Citation:
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PMID: 20400067 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The present work is concerned to model the molecular signalling pathway for vasodilation and to predict the resting young human forearm blood flow under heat stress. The mechanistic electronic modelling technique has been designed and implemented using MULTISIM 8.0 and an assumption of 1V/ degrees C for prediction of forearm blood flow and the digital logic has been used to design the molecular signalling pathway for vasodilation. The minimum forearm blood flow has been observed at 35 degrees C (0 ml 100 ml(-1)min(-1)) and the maximum at 42 degrees C (18.7 ml 100 ml(-1)min(-1)) environmental temperature with respect to the base value of 2 ml 100 ml(-1)min(-1). This model may also enable to identify many therapeutic targets that can be used in the treatment of inflammations and disorders due to heat-related illnesses. |
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Authors:
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Yogender Aggarwal; Bhuwan Mohan Karan; Barda Nand Das; Rakesh Kumar Sinha |
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Publication Detail:
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Type: Journal Article Date: 2010-04-18 |
Journal Detail:
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Title: Computers in biology and medicine Volume: 40 ISSN: 1879-0534 ISO Abbreviation: Comput. Biol. Med. Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-05-03 Completed Date: 2010-09-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 1250250 Medline TA: Comput Biol Med Country: United States |
Other Details:
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Languages: eng Pagination: 533-42 Citation Subset: IM |
Copyright Information:
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2010 Elsevier Ltd. All rights reserved. |
Affiliation:
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Department of Biomedical Instrumentation, Birla Institute of Technology, Mesra, Ranchi, Jharkhand, India. yogenderaggarwal@gmail.com <yogenderaggarwal@gmail.com> |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Biomimetic Materials* Blood Flow Velocity / physiology Computer Simulation Electronics Forearm / blood supply*, physiology* Heat-Shock Proteins / metabolism* Heat-Shock Response / physiology* Heme Oxygenase-1 / metabolism* Humans Models, Biological Proteome / metabolism Vasodilation / physiology* |
| Chemical | |
Reg. No./Substance:
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0/Heat-Shock Proteins; 0/Proteome; EC 1.14.99.3/HMOX1 protein, human; EC 1.14.99.3/Heme Oxygenase-1 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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