Document Detail


Mechanistic analysis of experimental food allergen-induced cutaneous reactions.
MedLine Citation:
PMID:  16861616     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Individuals with food allergy often present with uritcaria and atopic dermatitis. Indeed, susceptibility to food allergy may predispose to the development of these cutaneous allergic disorders. Recently, we developed a model of food allergy, whereby oral consumption of food [pea Pisum sativum L.; expressing alpha-amylase inhibitor-1 (alphaAI) from the common bean Phaseolus vulgaris L. cv Tendergreen (pea-alphaAI)] promotes a T helper cell type 2 (Th2) inflammatory response and predisposes to cutaneous allergic reactions following subsequent food allergen (alphaAI) exposure. To delineate the kinetics of food allergen-induced cutaneous reactions and examine the inflammatory mechanisms involved in this allergic reaction, we used interleukin (IL)-13-, IL-4 receptor alpha-, and eotaxin-1-deficient mice and performed serum transfer and CD4+ T cell depletion studies. We demonstrate that consumption of pea-alphaAI promotes an alphaAI-specific immunoglobulin G1 (IgG1) and IgE antibody response. Furthermore, we show that subsequent food allergen (alphaAI) challenge in the skin induced an early (3 h)- and late-phase (24 h) cutaneous allergic reaction. The early-phase response was associated with mast cell degranulation and the presence of Ig, whereas the late-phase response was characterized by a lymphoid and eosinophilic infiltrate, which was critically regulated by CD4+ T cells, IL-13, and eotaxin-1. Collectively, these studies demonstrate that food allergy can predispose to cutaneous inflammatory reactions, and these processes are critically regulated by Th2 immune factors.
Authors:
Vanessa E Prescott; Elizabeth Forbes; Paul S Foster; Klaus Matthaei; Simon P Hogan
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of leukocyte biology     Volume:  80     ISSN:  0741-5400     ISO Abbreviation:  J. Leukoc. Biol.     Publication Date:  2006 Aug 
Date Detail:
Created Date:  2006-07-24     Completed Date:  2006-09-22     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8405628     Medline TA:  J Leukoc Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  258-66     Citation Subset:  IM    
Affiliation:
Allergy and Inflammation Research Group, Division of Molecular Bioscience, The John Curtin School of Medical Research, Australian National University, Canberra, Australia.
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MeSH Terms
Descriptor/Qualifier:
Allergens / immunology*
Animals
Cell Degranulation
Cells, Cultured
Cytokines / physiology
Dermatitis, Atopic / immunology*
Eosinophils / immunology,  ultrastructure
Food Hypersensitivity / immunology*
Immunoglobulin E / blood
Immunoglobulin G / blood
Mast Cells / immunology
Mice
Mice, Inbred BALB C
Mice, Knockout
Peas / adverse effects*,  chemistry
Th2 Cells / physiology
Time Factors
alpha-Amylases / adverse effects,  antagonists & inhibitors*,  immunology*
Chemical
Reg. No./Substance:
0/Allergens; 0/Cytokines; 0/Immunoglobulin G; 37341-29-0/Immunoglobulin E; EC 3.2.1.1/alpha-Amylases

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