| Mechanistic basis of otolith formation during teleost inner ear development. | |
| | |
MedLine Citation:
|
PMID: 21316594 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Otoliths, which are connected to stereociliary bundles in the inner ear, serve as inertial sensors for balance. In teleostei, otolith development is critically dependent on flow forces generated by beating cilia; however, the mechanism by which flow controls otolith formation remains unclear. Here, we have developed a noninvasive flow probe using optical tweezers and a viscous flow model in order to demonstrate how the observed hydrodynamics influence otolith assembly. We show that rotational flow stirs and suppresses precursor agglomeration in the core of the cilia-driven vortex. The velocity field correlates with the shape of the otolith and we provide evidence that hydrodynamics is actively involved in controlling otolith morphogenesis. An implication of this hydrodynamic effect is that otolith self-assembly is mediated by the balance between Brownian motion and cilia-driven flow. More generally, this flow feature highlights an alternative biological strategy for controlling particle localization in solution. |
| | |
Authors:
|
David Wu; Jonathan B Freund; Scott E Fraser; Julien Vermot |
Related Documents
:
|
1544734 - Influence of blood handling techniques on lactic acid concentrations. 6769884 - Metabolic recovery from exhaustive activity by a large lizard. 27344 - Cellular microenvironment in relation to local blood flow. 19174 - A method for visual assessment of the performance of components in a continuous flow sy... 18003504 - Model based investigation of retinal vessel tortuosity as a function of blood pressure:... 11335054 - Sex differences in the cerebral blood flow response after brief hypercapnia in the rat. |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Developmental cell Volume: 20 ISSN: 1878-1551 ISO Abbreviation: Dev. Cell Publication Date: 2011 Feb |
Date Detail:
|
Created Date: 2011-02-14 Completed Date: 2011-04-01 Revised Date: 2011-09-22 |
Medline Journal Info:
|
Nlm Unique ID: 101120028 Medline TA: Dev Cell Country: United States |
Other Details:
|
Languages: eng Pagination: 271-8 Citation Subset: IM |
Copyright Information:
|
Copyright © 2011 Elsevier Inc. All rights reserved. |
Affiliation:
|
Biological Imaging Center, Beckman Institute, Option in Bioengineering, Caltech, Pasadena, CA 91125, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Biomechanics / physiology Cilia / physiology Diffusion Embryo, Nonmammalian / physiology Hydrodynamics Laser Therapy Movement / physiology Optical Tweezers Otolithic Membrane / embryology*, physiology* Rheology Viscosity Zebrafish / embryology* |
| Grant Support | |
ID/Acronym/Agency:
|
R01 HD043897-04/HD/NICHD NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Transcriptional activation of Arabidopsis axis patterning genes WOX8/9 links zygote polarity to embr...
Next Document: New insights into the origin and the genetic basis of rhabdomyosarcomas.