| Mechanisms of xenin-induced anorectic response in chicks (Gallus gallus). | |
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MedLine Citation:
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PMID: 18440536 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We recently reported that the 25 amino acid peptide xenin caused reduced feed intake when centrally injected in chicks. The present study was designed to explore possible mechanisms of the xenin-induced anorexigenic response in chicks. In Experiments 1 and 2, chicks were implanted with cannulas and xenin injections were made directly into the ventromedialis hypothalami (VMH). Chicks responded with reduced feed intake and increased c-Fos immunoreactivity at the VMH. In Experiment 3 chicks that received co-intracerebroventricular (ICV) injection of naloxone and a dose of xenin (100 pmol), that alone does not affect feed intake, had reduced feed intake. In Experiment 4, chicks responded to ICV xenin with reduced feed- but increased exploratory-pecking. Thus, we conclude that xenin may mediate its effect directly at the VMH and that the endogenous opioid system may counter anorexigenic effects of low xenin doses in chicks. Xenin also caused increased exploration of a novel environment, an effect that may be competitive with feeding. Taken together, these results suggest that xenin regulation of chick appetite is the result of several central and behavioral mechanisms acting in synergism. |
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Authors:
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Wint Nandar; Justin M Milligan; Mark A Cline |
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Publication Detail:
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Type: Journal Article Date: 2008-03-21 |
Journal Detail:
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Title: General and comparative endocrinology Volume: 157 ISSN: 1095-6840 ISO Abbreviation: Gen. Comp. Endocrinol. Publication Date: 2008 May |
Date Detail:
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Created Date: 2008-05-19 Completed Date: 2008-09-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370735 Medline TA: Gen Comp Endocrinol Country: United States |
Other Details:
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Languages: eng Pagination: 58-62 Citation Subset: IM |
Affiliation:
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Department of Neuroscience and Anatomy, Pennsylvania State University, P.O. Box 850, Hershey, PA 17033, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Analgesics, Opioid
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metabolism Animals Anorexia / chemically induced, metabolism*, physiopathology* Appetite Regulation / drug effects Chickens Eating / drug effects Feeding Behavior / drug effects Naloxone / administration & dosage, pharmacology Narcotic Antagonists / administration & dosage, pharmacology Peptides / administration & dosage, toxicity* Proto-Oncogene Proteins c-fos / metabolism Receptors, Opioid / antagonists & inhibitors, metabolism |
| Chemical | |
Reg. No./Substance:
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0/Analgesics, Opioid; 0/Narcotic Antagonists; 0/Peptides; 0/Proto-Oncogene Proteins c-fos; 0/Receptors, Opioid; 144092-28-4/xenin 25; 465-65-6/Naloxone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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