Document Detail

Mechanisms of xenin-induced anorectic response in chicks (Gallus gallus).
MedLine Citation:
PMID:  18440536     Owner:  NLM     Status:  MEDLINE    
We recently reported that the 25 amino acid peptide xenin caused reduced feed intake when centrally injected in chicks. The present study was designed to explore possible mechanisms of the xenin-induced anorexigenic response in chicks. In Experiments 1 and 2, chicks were implanted with cannulas and xenin injections were made directly into the ventromedialis hypothalami (VMH). Chicks responded with reduced feed intake and increased c-Fos immunoreactivity at the VMH. In Experiment 3 chicks that received co-intracerebroventricular (ICV) injection of naloxone and a dose of xenin (100 pmol), that alone does not affect feed intake, had reduced feed intake. In Experiment 4, chicks responded to ICV xenin with reduced feed- but increased exploratory-pecking. Thus, we conclude that xenin may mediate its effect directly at the VMH and that the endogenous opioid system may counter anorexigenic effects of low xenin doses in chicks. Xenin also caused increased exploration of a novel environment, an effect that may be competitive with feeding. Taken together, these results suggest that xenin regulation of chick appetite is the result of several central and behavioral mechanisms acting in synergism.
Wint Nandar; Justin M Milligan; Mark A Cline
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Publication Detail:
Type:  Journal Article     Date:  2008-03-21
Journal Detail:
Title:  General and comparative endocrinology     Volume:  157     ISSN:  1095-6840     ISO Abbreviation:  Gen. Comp. Endocrinol.     Publication Date:  2008 May 
Date Detail:
Created Date:  2008-05-19     Completed Date:  2008-09-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370735     Medline TA:  Gen Comp Endocrinol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  58-62     Citation Subset:  IM    
Department of Neuroscience and Anatomy, Pennsylvania State University, P.O. Box 850, Hershey, PA 17033, USA.
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MeSH Terms
Analgesics, Opioid / metabolism
Anorexia / chemically induced,  metabolism*,  physiopathology*
Appetite Regulation / drug effects
Eating / drug effects
Feeding Behavior / drug effects
Naloxone / administration & dosage,  pharmacology
Narcotic Antagonists / administration & dosage,  pharmacology
Peptides / administration & dosage,  toxicity*
Proto-Oncogene Proteins c-fos / metabolism
Receptors, Opioid / antagonists & inhibitors,  metabolism
Reg. No./Substance:
0/Analgesics, Opioid; 0/Narcotic Antagonists; 0/Peptides; 0/Proto-Oncogene Proteins c-fos; 0/Receptors, Opioid; 144092-28-4/xenin 25; 465-65-6/Naloxone

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