| Mechanisms of ventricular fibrillation induction by 60-Hz alternating current in isolated swine right ventricle. | |
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MedLine Citation:
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PMID: 11004149 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The mechanisms by which 60-Hz alternating current (AC) can induce ventricular fibrillation (VF) are unknown. METHODS AND RESULTS: We studied 7 isolated perfused swine right ventricles in vitro. The action potential duration restitution curve was determined. Optical mapping techniques were used to determine the patterns of activation on the epicardium during 5-second 60-Hz AC stimulation (10 to 999 microA). AC captured the right ventricles at 100+/-65 microA, which is significantly lower than the direct current pacing threshold (0.77+/-0.45 mA, P:<0.05). AC induced ventricular tachycardia or VF at 477+/-266 microA, when the stimulated responses to AC had (1) short activation CLs (128+/-14 ms), (2) short diastolic intervals (16+/-9 ms), and (3) short diastolic intervals associated with a steep action potential duration restitution curve. Optical mapping studies showed that during rapid ventricular stimulation by AC, a wave front might encounter the refractory tail of an earlier wave front, resulting in the formation of a wave break and VF. Computer simulations reproduced these results. CONCLUSIONS: AC at strengths less than the regular pacing threshold can capture the ventricle at fast rates. Accidental AC leak to the ventricles could precipitate VF and sudden death if AC results in a fast ventricular rate coupled with a steep restitution curve and a nonuniform recovery of excitability of the myocardium. |
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Authors:
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O Voroshilovsky; Z Qu; M H Lee; T Ohara; G A Fishbein; H L Huang; C D Swerdlow; S F Lin; A Garfinkel; J N Weiss; H S Karagueuzian; P S Chen |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Circulation Volume: 102 ISSN: 1524-4539 ISO Abbreviation: Circulation Publication Date: 2000 Sep |
Date Detail:
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Created Date: 2000-09-29 Completed Date: 2001-02-22 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0147763 Medline TA: Circulation Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1569-74 Citation Subset: IM |
Affiliation:
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Division of Cardiology, Department of Medicine, Cedars-Sinai Medical Center, UCLA School of Medicine, Los Angeles, CA 90048, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Electricity / adverse effects* Heart Ventricles / physiopathology Swine Time Factors Ventricular Fibrillation / etiology*, physiopathology |
| Grant Support | |
ID/Acronym/Agency:
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HL-44880/HL/NHLBI NIH HHS; HL-58533/HL/NHLBI NIH HHS; P50-HL-52319/HL/NHLBI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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