| Mechanisms of vascular stability and the relationship to human disease. | |
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MedLine Citation:
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PMID: 20308891 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE OF REVIEW: The genetic basis for a variety of vascular malformation syndromes have been described, with an increasing functional understanding of the associated genes. RECENT FINDINGS: Genes responsible for familial vascular malformation syndromes have increasingly been shown to be involved in the control of vascular stability. SUMMARY: Genes involved in vascular stability pathways are good candidates for causing vascular malformation syndromes. Although these findings confirm the biologic importance of the involved pathways, further explanations are required to describe the focal nature of disease. |
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Authors:
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Matthew C P Smith; Dean Y Li; Kevin J Whitehead |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Current opinion in hematology Volume: 17 ISSN: 1531-7048 ISO Abbreviation: Curr. Opin. Hematol. Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-04-15 Completed Date: 2010-07-29 Revised Date: 2011-07-28 |
Medline Journal Info:
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Nlm Unique ID: 9430802 Medline TA: Curr Opin Hematol Country: United States |
Other Details:
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Languages: eng Pagination: 237-44 Citation Subset: IM |
Affiliation:
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Molecular Medicine Program, Department of Oncological Sciences, University of Utah, Salt Lake City, Utah, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Vessels / cytology, physiology* Humans Vascular Diseases / etiology*, metabolism |
| Grant Support | |
ID/Acronym/Agency:
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K08 HL079095-04/HL/NHLBI NIH HHS; R01 HL065648-05A2/HL/NHLBI NIH HHS; R01 HL068873-07/HL/NHLBI NIH HHS; R01 HL068873-08/HL/NHLBI NIH HHS; R01 HL077671-05A1/HL/NHLBI NIH HHS; R01 HL084516-03/HL/NHLBI NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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