| Mechanisms of vascular dysfunctionin insulin resistance. | |
| | |
MedLine Citation:
|
PMID: 15503646 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Insulin resistance (IR) has profound, negative effects on the function of arteries and arterioles throughout the body. In addition to the obvious link between IR and the development of type 2 diabetes, IR-associated dysfunction of resistance vessels is associated with arterial hypertension and vascular occlusive diseases, such as heart attacks and strokes. IR affects arteries and arterioles at both the endothelium and smooth muscle levels. For example, IR causes reduced responsiveness of vascular smooth muscle to dilator agents; predominantly due to impaired potassium channel function. The common, underlying mechanism of vascular dysfunction, at both endothelium and smooth muscle levels, appears to involve the augmented availability and subsequent actions of reactive oxygen species (ROS). However, in some circulations, other factors, such as increased production of, and actions by, constrictor agents also appear to restrict normal dilator responses. The underlying cause of augmented ROS availability is not completely understood, but vascular inflammatory processes appear to be involved. Furthermore, application of superoxide dismutase, a specific scavenger of superoxide anion, is able to immediately restore normal vascular responsiveness in IR arteries. Additional treatments involving behavioral and pharmacological approaches, such as dietary adjustments, weight loss, exercise and the use of statins or insulin-sensitizing agents also appear to offer some benefit against the detrimental effects of IR. |
| | |
Authors:
|
David W Busija; Allison W Miller; Prasad Katakam; Steve Simandle; Benedek Erdös |
Related Documents
:
|
16284236 - Effect of acute sympathetic nervous system activation on flow-mediated dilation of brac... 18347666 - Introduction to proceedings from the 2005 csep symposium "exercise and the endothelium". 10727066 - Nitric oxide biomarkers increase during exercise-induced vasodilation in the forearm. 9893736 - Syndrome x and endothelial dysfunction. 16923446 - Effect of enhanced external counterpulsation on resting oxygen uptake in patients havin... 7601876 - Effect of foot-progression angle on hip joint moments during gait. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
|
Title: Current opinion in investigational drugs (London, England : 2000) Volume: 5 ISSN: 1472-4472 ISO Abbreviation: Curr Opin Investig Drugs Publication Date: 2004 Sep |
Date Detail:
|
Created Date: 2004-10-26 Completed Date: 2005-01-25 Revised Date: 2007-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 100965718 Medline TA: Curr Opin Investig Drugs Country: England |
Other Details:
|
Languages: eng Pagination: 929-35 Citation Subset: IM |
Affiliation:
|
Wake Forest University Health Sciences, Department of Physiology and Pharmacology, Winston-Salem, NC 27157-1023, USA. dbusija@wfubmc.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Brain / blood supply Diabetes Mellitus, Type 2 / complications, metabolism, physiopathology Diabetic Angiopathies / etiology, physiopathology* Endothelium-Dependent Relaxing Factors / physiology Humans Insulin Resistance / physiology* Potassium Channels / physiology Reactive Oxygen Species / metabolism |
| Grant Support | |
ID/Acronym/Agency:
|
DK-62372/DK/NIDDK NIH HHS; HL-30260/HL/NHLBI NIH HHS; HL-50587/HL/NHLBI NIH HHS; HL-65380/HL/NHLBI NIH HHS; HL-66074/HL/NHLBI NIH HHS; HL-77731/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Endothelium-Dependent Relaxing Factors; 0/Potassium Channels; 0/Reactive Oxygen Species |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Housing plus services: supporting vulnerable families in permanent housing.
Next Document: PPARs as targets for the modulation of cardiovascular risk factors associated with the metabolic syn...