Document Detail


Mechanisms underpinning exercise-induced changes in left ventricular function.
MedLine Citation:
PMID:  18614953     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Despite a growing body of evidence suggesting that prolonged strenuous exercise (PSE) is associated with a transient reduction in right (RV) and left ventricular (LV) performance, the exact mechanism(s) responsible for this phenomenon is not fully understood. As such, the primary objective of this article was to critically review the available literature (both animal and human) to provide insight into the potential mechanism(s) responsible for the development of "exercise-induced cardiac fatigue." We pay particular attention to the major mechanisms that have been linked to transient changes in systolic function after PSE including altered loading conditions, myocardial ischemia/damage, altered beta-receptor responsiveness, and altered cardiac autonomic modulation. We also examine the potential mechanisms that may contribute to transient changes in diastolic function often observed after PSE including changes in LV pressure gradients and alterations in intrinsic myocardial relaxation. Although further mechanistic investigations are clearly warranted, several key mechanisms have received support for at least a partial contribution to the transient changes in myocardial performance often observed after PSE.
Authors:
Jessica M Scott; Darren E R Warburton
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Medicine and science in sports and exercise     Volume:  40     ISSN:  1530-0315     ISO Abbreviation:  Med Sci Sports Exerc     Publication Date:  2008 Aug 
Date Detail:
Created Date:  2008-07-18     Completed Date:  2008-12-31     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8005433     Medline TA:  Med Sci Sports Exerc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1400-7     Citation Subset:  IM; S    
Affiliation:
Cardiovascular Physiology and Rehabilitation Laboratory, University of British Columbia, Vancouver, British Columbia, Canada. jmscott@interchange.ubc.ca
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MeSH Terms
Descriptor/Qualifier:
Animals
Diastole / physiology
Exercise / physiology*
Fatigue / physiopathology
Humans
Physical Endurance / physiology
Time Factors
Ventricular Dysfunction, Left / etiology*,  physiopathology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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