Document Detail

Mechanisms underlying stimulation of gastroduodenal HCO3- secretion by NG-nitro-L-arginine methyl ester, an inhibitor of nitric oxide synthase, in rats.
MedLine Citation:
PMID:  7869616     Owner:  NLM     Status:  MEDLINE    
We investigated the mechanism underlying stimulation of HCO3- secretion by the nitric oxide (NO) synthase inhibitor NG-nitro-L-arginine methyl ester (L-NAME) in the gastroduodenal mucosa of anesthetized rats. A chambered stomach (in the presence of omeprazole) or a duodenal loop was perfused with saline, and HCO3- secretion was measured at pH 7.0 by a pH-stat method. Intravenous administration of L-NAME increased gastroduodenal HCO3- secretion with a concomitant rise in arterial blood pressure and a decrease in heart rate, and the changes were all antagonized by simultaneous administration of L-arginine. Vagotomy had no effect on the increased blood pressure response, but significantly inhibited the decrease of heart rate and increase of HCO3- secretion caused by L-NAME. The HCO3- stimulatory action of L-NAME was also inhibited by prior administration of yohimbine or prazosin. These agents alone lowered blood pressure and reduced the magnitude of the blood pressure response caused by L-NAME, leading to inhibition of heart rate changes. When delta HCO3- output induced by L-NAME was plotted against delta blood pressure change (from basal values) under various conditions, a significant relationship was found between these two factors. These results suggest that L-NAME stimulates gastroduodenal HCO3- secretion in association with the inhibition of endogenous NO production, and this mechanism may be in part mediated by a neural reflex through the vagal efferent nerve, resulting from the pressor response to L-NAME.
K Takeuchi; K Takehara; S Okabe
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Japanese journal of pharmacology     Volume:  66     ISSN:  0021-5198     ISO Abbreviation:  Jpn. J. Pharmacol.     Publication Date:  1994 Nov 
Date Detail:
Created Date:  1995-03-30     Completed Date:  1995-03-30     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  2983305R     Medline TA:  Jpn J Pharmacol     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  295-302     Citation Subset:  IM    
Department of Applied Pharmacology, Kyoto Pharmaceutical University, Japan.
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MeSH Terms
Arginine / analogs & derivatives*,  pharmacology
Bicarbonates / metabolism*
Blood Pressure / drug effects
Dose-Response Relationship, Drug
Duodenum / drug effects*,  metabolism
Gastric Mucosa / drug effects*,  metabolism
Heart Rate / drug effects
Intestinal Mucosa / drug effects,  metabolism
NG-Nitroarginine Methyl Ester
Nitric Oxide / antagonists & inhibitors*
Prazosin / pharmacology
Rats, Sprague-Dawley
Stimulation, Chemical
Yohimbine / pharmacology
Reg. No./Substance:
0/Bicarbonates; 10102-43-9/Nitric Oxide; 146-48-5/Yohimbine; 19216-56-9/Prazosin; 50903-99-6/NG-Nitroarginine Methyl Ester; 74-79-3/Arginine

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