Document Detail

Mechanisms underlying the role of glucocorticoids in the early life programming of adult disease.
MedLine Citation:
PMID:  17663659     Owner:  NLM     Status:  MEDLINE    
Compelling epidemiological evidence suggests that exposure to an adverse intrauterine environment, manifested by low-birth weight, is associated with cardiometabolic and behavioural disorders in adulthood. These observations have led to the concept of 'fetal programming'. The molecular mechanisms that underlie this relationship remain unclear, but are being extensively investigated using a number of experimental models. One major hypothesis for early life physiological programming implicates fetal overexposure to stress (glucocorticoid) hormones. Several animal studies have shown that prenatal glucocorticoid excess, either from endogenous overproduction with maternal stress or through exogenous administration to the mother or fetus, reduces birth weight and causes lifelong hypertension, hyperglycaemia and behavioural abnormality in the offspring. Intriguingly, these effects are transmitted across generations without further exposure to glucocorticoids, which suggests an epigenetic mechanism. These animal observations could have huge implications if extrapolated to humans, where glucocorticoids have extensive therapeutic use in obstetric and neonatal practice.
Amanda J Drake; Justin I Tang; Moffat J Nyirenda
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Clinical science (London, England : 1979)     Volume:  113     ISSN:  1470-8736     ISO Abbreviation:  Clin. Sci.     Publication Date:  2007 Sep 
Date Detail:
Created Date:  2007-07-31     Completed Date:  2007-09-17     Revised Date:  2014-02-19    
Medline Journal Info:
Nlm Unique ID:  7905731     Medline TA:  Clin Sci (Lond)     Country:  England    
Other Details:
Languages:  eng     Pagination:  219-32     Citation Subset:  IM    
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MeSH Terms
Fetal Development / physiology*
Glucocorticoids / physiology*
Hyperglycemia / embryology
Hypertension / embryology
Infant, Low Birth Weight
Infant, Newborn
Prenatal Exposure Delayed Effects*
Stress, Psychological*
Grant Support
G0501904//Medical Research Council; G0501934//Medical Research Council
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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