| Mechanisms underlying overshoot dilation after sympathetic denervation. | |
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MedLine Citation:
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PMID: 687833 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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(1) 30--60 sec after transection of the sympathetic chain, the diameter of both femoral artery and vein dilates to approximately 120% of the control diameter ('overshoot dilation'). Vessel diameter subsequently decreases and stabilizes with 5--10 min at a value of 108% of the original ('stabilized dilation'). (2) After treatment with norepinephrine-uptake-blocking drugs (cocaine, imipramine), the transient overshoot dilation is abolished and the diameter 1 min after denervation is identical to that at stabilized dilation. (3) It is proposed that (a) the stabilized rather than the transient overshoot dilation represents the loss of sympathetic control following following denervation and (b) the overshoot dilation reflects a transient decrease in transmitter concentration within the vessel wall, associated with a temporarily undiminished rate of neural reuptake activity persisting even in the absence of transmitter release. |
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Authors:
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J Gero; M Gerová |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Blood vessels Volume: 15 ISSN: 0303-6847 ISO Abbreviation: Blood Vessels Publication Date: 1978 |
Date Detail:
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Created Date: 1978-11-29 Completed Date: 1978-11-29 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0427130 Medline TA: Blood Vessels Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 277-85 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Arteries / innervation* Cocaine / pharmacology Dogs Female Femoral Artery / innervation Femoral Vein / innervation Imipramine / pharmacology Male Neurons / metabolism Norepinephrine / metabolism Sympathectomy Sympathetic Nervous System / drug effects, physiology* Vasodilation* / drug effects Vasomotor System / physiology Veins / innervation* |
| Chemical | |
Reg. No./Substance:
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50-36-2/Cocaine; 50-49-7/Imipramine; 51-41-2/Norepinephrine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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