| Mechanisms underlying the cholesterol-lowering properties of soluble dietary fibre polysaccharides. | |
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MedLine Citation:
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PMID: 21776465 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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A number of studies have shown a positive relationship between diets rich in soluble dietary fibres (SDF) such as β-glucan, pectin, guar gum and psyllium, and reduced serum cholesterol and thus a decreased risk of cardiovascular disease (CVD). Three major biological mechanisms have been proposed to explain the cholesterol-reducing effects of SDF: prevention of bile salt (BS) re-absorption from the small intestine leading to an excess faecal BS excretion; reduced glycemic response leading to lower insulin stimulation of hepatic cholesterol synthesis; and physiological effects of fermentation products of SDF, mainly propionate. Evidence for the latter mechanism is inconclusive, whereas in vivo, ex vivo and in vitro experiments suggest that BS micelles "bind" to SDF preventing their re-absorption. Whereas, glycemic responses to SDF have been studied extensively, the nature of interactions between bile salt micelles and SDF that lead to incomplete BS re-absorption are poorly defined. Three potential physicochemical mechanisms are proposed together with suggestions for in vitro experiments to test them. |
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Authors:
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Purnima Gunness; Michael John Gidley |
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Publication Detail:
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Type: Journal Article Date: 2010-09-30 |
Journal Detail:
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Title: Food & function Volume: 1 ISSN: 2042-650X ISO Abbreviation: Food Funct Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2011-07-21 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101549033 Medline TA: Food Funct Country: England |
Other Details:
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Languages: eng Pagination: 149-55 Citation Subset: IM |
Affiliation:
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Centre for Nutrition and Food Sciences, The University of Queensland, Hartley Teakle Building, St Lucia, Queensland 4072, Australia. m.gidley@uq.edu.au. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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