Document Detail

Mechanisms of twinning. II. Laterality and intercellular bonding in monozygotic twinning.
MedLine Citation:
PMID:  11396375     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To utilize observations on laterality and handedness to gain insight into the initiating mechanism of monozygotic human quadruplets. STUDY DESIGN: In a study of thumbprints and handedness in sets of monozygotic quadruplets, homolateral and heterolateral comparisons were used to distinguish mirror-image from symmetric divisions. RESULTS: Data were consistent with a mechanism involving a mirror-image duplication in the first division and a subsequent symmetric separation of the daughters. In addition, these data failed to substantiate a genetic linkage between dermatoglyphics and handedness. CONCLUSION: Reported and reviewed data tend to support the analogy of monozygotic polyembryony in armadillos and humans. The plausible roles of delayed implantation and intercellular bonding are explored, especially as they relate to ambient calcium concentration. Factors tending to enhance the likelihood of monozygotic twinning include calcium channel blockers, lactation, ovulation induction and prolonged in vitro fertilization incubation.
G Steinman
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of reproductive medicine     Volume:  46     ISSN:  0024-7758     ISO Abbreviation:  J Reprod Med     Publication Date:  2001 May 
Date Detail:
Created Date:  2001-06-08     Completed Date:  2001-10-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0173343     Medline TA:  J Reprod Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  473-9     Citation Subset:  IM    
Department of Obstetrics and Gynecology, Long Island Jewish Medical Center, New Hyde Park, New York, USA.
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MeSH Terms
Functional Laterality / genetics*
Linkage (Genetics)
Pregnancy, Multiple*
Twins, Monozygotic / genetics*

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