| Mechanisms of transcriptional activation of the col6a1 gene during Schwann cell differentiation. | |
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MedLine Citation:
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PMID: 11287188 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A transgenic mouse line expressing the lacZ reporter under the control of a regulatory region of the col6a1 gene has been used to investigate differentiation of Schwann cells. The data suggest that: (1) activation of col6a1 gene transcription in the peripheral nervous system is part of the differentiation program of Schwann cells from neural crest cells stimulated by neuregulins; (2) once the Schwann cell precursors have acquired the competence of transcribing the col6a1 gene, transcriptional regulation becomes independent from neuregulins and is modulated by different mechanisms, including cell cycle; (3) activation of transgene expression after birth in sciatic nerves corresponds to the time of withdrawal of immature Schwann cells from the cell cycle and the beginning of their differentiation into myelinating Schwann cells. |
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Authors:
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P Vitale; P Braghetta; D Volpin; P Bonaldo; G M Bressan |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Mechanisms of development Volume: 102 ISSN: 0925-4773 ISO Abbreviation: Mech. Dev. Publication Date: 2001 Apr |
Date Detail:
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Created Date: 2001-04-05 Completed Date: 2001-08-16 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 9101218 Medline TA: Mech Dev Country: Ireland |
Other Details:
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Languages: eng Pagination: 145-56 Citation Subset: IM |
Affiliation:
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Department of Histology, Microbiology and Medical Biotechnologies, University of Padova, Via G. Colombo 3, 35100, Padova, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Axons / metabolism Bromodeoxyuridine / metabolism Cell Cycle Cell Differentiation Cells, Cultured Collagen / genetics*, metabolism* Ganglia, Spinal / cytology In Situ Hybridization Mice Mice, Transgenic Myelin Sheath / metabolism Neurofilament Proteins / metabolism Peripheral Nervous System / embryology Phenotype Schwann Cells / metabolism* Stem Cells / cytology Time Factors Transcription, Genetic Transcriptional Activation* Transgenes beta-Galactosidase / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Neurofilament Proteins; 59-14-3/Bromodeoxyuridine; 9007-34-5/Collagen; EC 3.2.1.23/beta-Galactosidase |
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