| Mechanisms to explain the poor results of carotid artery stenting (CAS) in symptomatic patients to date and options to improve CAS outcomes. | |
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MedLine Citation:
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PMID: 20638227 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Carotid artery stenting (CAS) is considered by many as an alternative to carotid endarterectomy (CEA) for the management of carotid artery stenosis. However, recent trials demonstrated inferior results for CAS in symptomatic patients compared with CEA. We reviewed the literature to evaluate the appropriateness of CAS for symptomatic carotid artery stenosis and to determine the pathogenetic mechanism(s) associated with stroke following the treatment of such lesions. Based on this, we propose steps to improve the results of CAS for the treatment of symptomatic carotid stenosis. METHODS: PubMed/Medline was searched up to March 25, 2010 for studies investigating the efficacy of CAS for the management of symptomatic carotid stenosis. Search terms used were "carotid artery stenting," "symptomatic carotid artery stenosis," "carotid endarterectomy," "stroke," "recurrent carotid stenosis," and "long-term results" in various combinations. RESULTS: Current data suggest that CAS is not equivalent to CEA for the treatment of symptomatic carotid stenosis. Differences in carotid plaque morphology and a higher incidence of microemboli and cerebrovascular events during and after CAS compared with CEA may account for these inferior results. CONCLUSIONS: Currently, most symptomatic patients are inappropriate candidates for CAS. Improved CAS technology referable to stent design and embolic protection strategies may alter this conclusion in the future. |
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Authors:
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Kosmas I Paraskevas; Dimitri P Mikhailidis; Frank J Veith |
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Publication Detail:
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Type: Journal Article; Review Date: 2010-07-17 |
Journal Detail:
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Title: Journal of vascular surgery : official publication, the Society for Vascular Surgery [and] International Society for Cardiovascular Surgery, North American Chapter Volume: 52 ISSN: 1097-6809 ISO Abbreviation: J. Vasc. Surg. Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-11-05 Completed Date: 2010-12-10 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8407742 Medline TA: J Vasc Surg Country: United States |
Other Details:
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Languages: eng Pagination: 1367-75 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Society for Vascular Surgery. Published by Mosby, Inc. All rights reserved. |
Affiliation:
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Department of Vascular Surgery, Red Cross Hospital, Athens, Greece. paraskevask@hotmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Angioplasty
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adverse effects*,
instrumentation* Carotid Stenosis / complications, surgery, therapy* Endarterectomy, Carotid Humans Patient Selection Risk Assessment Risk Factors Stents* Stroke / etiology* Treatment Outcome |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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