| Mechanisms for the tachypneic response to the thromboxane A2 mimetic U-46,619 in rabbits. | |
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MedLine Citation:
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PMID: 8141386 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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These experiments were designed to determine if intravenous infusion of the thromboxane A2 mimetic, U-46,619, would elicit tachypnea in the rabbit, and if so whether the afferent signal was generated by receptors innervated by myelinated or unmyelinated vagal nerve fibers. Intravenous infusion of U-46,619 (0.5 microgram/kg delivered over 10 s) increased breathing frequency (26%) and right ventricular blood pressure (59%) in the anesthetized rabbit (n = 10). Systemic arterial blood pressure, heart rate, and tidal volume were unaffected by the infusion of U-46,619. When myelinated fiber conduction in the vagus nerve was eliminated by bilaterally cooling the nerve to 6 degrees C, the increase in breathing frequency was only 5% above baseline levels. The tachypneic response to U-46,619 was totally eliminated when both myelinated and unmyelinated fiber conduction was abolished by cooling the vagi to 0 degree C. The increase in right ventricular blood pressure after U-46,619 infusion was unaffected by vagal cooling. Because most (> 80%) of the tachypneic response to U-46,619 was eliminated by blockade of myelinated vagal fiber conduction, we conclude that the tachypneic response to U-46,619 is mediated mostly by receptors innervated by myelinated vagal afferent fibers in the anesthetized rabbit. |
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Authors:
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J A Carrithers; F Liu; H W Shirer; J A Orr |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The American journal of physiology Volume: 266 ISSN: 0002-9513 ISO Abbreviation: Am. J. Physiol. Publication Date: 1994 Feb |
Date Detail:
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Created Date: 1994-04-26 Completed Date: 1994-04-26 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370511 Medline TA: Am J Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: R321-7 Citation Subset: IM |
Affiliation:
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Department of Physiology and Cell Biology, University of Kansas, Lawrence 66045. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid Afferent Pathways / physiology Animals Blood Pressure / drug effects Feedback Female Heart Rate / drug effects Male Muscle, Smooth / drug effects, physiology Nerve Fibers / drug effects, physiology Nerve Fibers, Myelinated / drug effects, physiology Neural Conduction / drug effects Prostaglandin Endoperoxides, Synthetic / pharmacology* Rabbits Respiration / drug effects* Thromboxane A2 / analogs & derivatives*, pharmacology Tidal Volume / drug effects Trachea / drug effects, physiology Vagus Nerve / physiology* Vasoconstrictor Agents / pharmacology Ventricular Function, Right / drug effects, physiology |
| Chemical | |
Reg. No./Substance:
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0/Prostaglandin Endoperoxides, Synthetic; 0/Vasoconstrictor Agents; 57576-52-0/Thromboxane A2; 76898-47-0/15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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