Document Detail

Mechanisms of stress (Takotsubo) cardiomyopathy.
MedLine Citation:
PMID:  20195267     Owner:  NLM     Status:  MEDLINE    
Stress cardiomyopathy, also referred to as Takotsubo cardiomyopathy, transient apical ballooning or broken heart syndrome, is a disorder associated with transient left ventricular dysfunction. Symptoms include acute chest pain and dyspnea accompanied by electrocardiographic changes, such as ST-segment elevation and T-wave inversions, minimal elevation of cardiac enzyme levels and transient wall-motion abnormalities in the absence of substantial coronary artery obstruction. Complete recovery of contractile function has been documented in nearly all cases, but the mechanisms of disease remain unclear and the cause has not been established. Coronary artery vasospasm, microcirculation dysfunction, and transient obstruction of the left ventricular outflow tract have been proposed as possible causes of this disorder. An excessive release of catecholamines also seems to have a pivotal role in the development of stress cardiomyopathy. This Review summarizes published data on stress cardiomyopathy, focusing primarily on the most likely causes of this cardiac entity.
Holger M Nef; Helge Möllmann; Yoshihiro J Akashi; Christian W Hamm
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Publication Detail:
Type:  Journal Article; Review     Date:  2010-03-02
Journal Detail:
Title:  Nature reviews. Cardiology     Volume:  7     ISSN:  1759-5010     ISO Abbreviation:  Nat Rev Cardiol     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-03-29     Completed Date:  2010-07-21     Revised Date:  2012-07-12    
Medline Journal Info:
Nlm Unique ID:  101500075     Medline TA:  Nat Rev Cardiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  187-93     Citation Subset:  IM    
Department of Cardiology, Kerckhoff Heart and Thorax Center, 61231 Bad Nauheim, Germany.
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MeSH Terms
Acute Disease
Catecholamines / blood
Coronary Vasospasm / complications
Disease Models, Animal
Risk Factors
Sarcoplasmic Reticulum Calcium-Transporting ATPases / metabolism
Stress, Psychological / complications*,  physiopathology
Sympathetic Nervous System / physiopathology
Takotsubo Cardiomyopathy / epidemiology,  etiology*,  physiopathology*
United States / epidemiology
Ventricular Dysfunction, Left
Ventricular Outflow Obstruction / complications
Reg. No./Substance:
0/Catecholamines; EC protein, human; EC Reticulum Calcium-Transporting ATPases

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