| Mechanisms of stress (Takotsubo) cardiomyopathy. | |
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MedLine Citation:
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PMID: 20195267 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Stress cardiomyopathy, also referred to as Takotsubo cardiomyopathy, transient apical ballooning or broken heart syndrome, is a disorder associated with transient left ventricular dysfunction. Symptoms include acute chest pain and dyspnea accompanied by electrocardiographic changes, such as ST-segment elevation and T-wave inversions, minimal elevation of cardiac enzyme levels and transient wall-motion abnormalities in the absence of substantial coronary artery obstruction. Complete recovery of contractile function has been documented in nearly all cases, but the mechanisms of disease remain unclear and the cause has not been established. Coronary artery vasospasm, microcirculation dysfunction, and transient obstruction of the left ventricular outflow tract have been proposed as possible causes of this disorder. An excessive release of catecholamines also seems to have a pivotal role in the development of stress cardiomyopathy. This Review summarizes published data on stress cardiomyopathy, focusing primarily on the most likely causes of this cardiac entity. |
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Authors:
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Holger M Nef; Helge Möllmann; Yoshihiro J Akashi; Christian W Hamm |
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Publication Detail:
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Type: Journal Article; Review Date: 2010-03-02 |
Journal Detail:
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Title: Nature reviews. Cardiology Volume: 7 ISSN: 1759-5010 ISO Abbreviation: Nat Rev Cardiol Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-03-29 Completed Date: 2010-07-21 Revised Date: 2012-07-12 |
Medline Journal Info:
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Nlm Unique ID: 101500075 Medline TA: Nat Rev Cardiol Country: England |
Other Details:
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Languages: eng Pagination: 187-93 Citation Subset: IM |
Affiliation:
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Department of Cardiology, Kerckhoff Heart and Thorax Center, 61231 Bad Nauheim, Germany. h.nef@kerckhoff-fgi.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Animals Catecholamines / blood Coronary Vasospasm / complications Disease Models, Animal Humans Microcirculation Prevalence Risk Factors Sarcoplasmic Reticulum Calcium-Transporting ATPases / metabolism Stress, Psychological / complications*, physiopathology Sympathetic Nervous System / physiopathology Takotsubo Cardiomyopathy / epidemiology, etiology*, physiopathology* United States / epidemiology Ventricular Dysfunction, Left Ventricular Outflow Obstruction / complications |
| Chemical | |
Reg. No./Substance:
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0/Catecholamines; EC 3.6.3.8/ATP2A2 protein, human; EC 3.6.3.8/Sarcoplasmic Reticulum Calcium-Transporting ATPases |
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