| Mechanisms sensing and modulating signals arising from cell swelling. | |
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MedLine Citation:
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PMID: 12438761 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cell volume alterations are involved in numerous cellular events like epithelial transport, metabolic processes, hormone secretion, cell migration, proliferation and apoptosis. Above all it is a need for every cell to counteract osmotic cell swelling in order to avoid cell damage. The defence against excess cell swelling is accomplished by a reduction of the intracellular osmolarity by release of organic- or inorganic osmolytes from the cell or by synthesis of osmotically less active macromolecules from their specific subunits. De-spite the large amount of experimental data that has accumulated, the intracellular mechanisms underlying the sensing of cell volume perturbations and the activation of volume compensatory processes, commonly summarized as regulatory volume decrease (RVD), are still only partly revealed. Moving into this field opens a complex scenario of molecular rearrangements and interactions involving intracellular messengers such as calcium, phosphoinositides and inositolphosphates as well as phosphoryla-tion/dephosphorylation processes and cytoskeletal reorganization with marked cell type- and tissue specific variations. Even in one and the same cell type significant differences regarding the activated pathways during RVD may be evident. This makes it virtually im-possible to unambigously define common sensing- and sinaling pathways used by differ-ent cells to readjust their celll volume, even if all these pathways converge to the activa-tion of comparatively few sets of effectors serving for osmolyte extrusion, including ion channels and transporters. This review is aimed at providing an insight into the manifold cellular mechanisms and alterations occuring during cell swelling and RVD. |
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Authors:
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Martin Jakab; Johannes Fürst; Martin Gschwentner; Guido Bottà; Maria-Lisa Garavaglia; Claudia Bazzini; Simona Rodighiero; Giuliano Meyer; Sonja Eichmueller; Eichmüller Wöll; Sabine Chwatal; Markus Ritter; Markus Paulmichl |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology Volume: 12 ISSN: 1015-8987 ISO Abbreviation: Cell. Physiol. Biochem. Publication Date: 2002 |
Date Detail:
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Created Date: 2002-11-19 Completed Date: 2003-06-10 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9113221 Medline TA: Cell Physiol Biochem Country: Switzerland |
Other Details:
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Languages: eng Pagination: 235-58 Citation Subset: IM |
Copyright Information:
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Copyright 2002 S. Karger AG, Basel |
Affiliation:
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Institute of Physiology, University of Innsbruck, Austria. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Arachidonic Acid / pharmacology Autocrine Communication / physiology Calcium / metabolism Cell Membrane / physiology Cell Size / physiology* Cytoskeleton / metabolism Eicosanoids / pharmacology Humans Inositol Phosphates / metabolism, pharmacology Ion Channels / metabolism Osmosis / physiology Phosphatidylinositols / metabolism, pharmacology Phosphorylation Receptors, Purinergic P2 / metabolism Signal Transduction / physiology* |
| Chemical | |
Reg. No./Substance:
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0/Eicosanoids; 0/Inositol Phosphates; 0/Ion Channels; 0/Phosphatidylinositols; 0/Receptors, Purinergic P2; 506-32-1/Arachidonic Acid; 7440-70-2/Calcium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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