Document Detail

Mechanisms sensing and modulating signals arising from cell swelling.
MedLine Citation:
PMID:  12438761     Owner:  NLM     Status:  MEDLINE    
Cell volume alterations are involved in numerous cellular events like epithelial transport, metabolic processes, hormone secretion, cell migration, proliferation and apoptosis. Above all it is a need for every cell to counteract osmotic cell swelling in order to avoid cell damage. The defence against excess cell swelling is accomplished by a reduction of the intracellular osmolarity by release of organic- or inorganic osmolytes from the cell or by synthesis of osmotically less active macromolecules from their specific subunits. De-spite the large amount of experimental data that has accumulated, the intracellular mechanisms underlying the sensing of cell volume perturbations and the activation of volume compensatory processes, commonly summarized as regulatory volume decrease (RVD), are still only partly revealed. Moving into this field opens a complex scenario of molecular rearrangements and interactions involving intracellular messengers such as calcium, phosphoinositides and inositolphosphates as well as phosphoryla-tion/dephosphorylation processes and cytoskeletal reorganization with marked cell type- and tissue specific variations. Even in one and the same cell type significant differences regarding the activated pathways during RVD may be evident. This makes it virtually im-possible to unambigously define common sensing- and sinaling pathways used by differ-ent cells to readjust their celll volume, even if all these pathways converge to the activa-tion of comparatively few sets of effectors serving for osmolyte extrusion, including ion channels and transporters. This review is aimed at providing an insight into the manifold cellular mechanisms and alterations occuring during cell swelling and RVD.
Martin Jakab; Johannes Fürst; Martin Gschwentner; Guido Bottà; Maria-Lisa Garavaglia; Claudia Bazzini; Simona Rodighiero; Giuliano Meyer; Sonja Eichmueller; Eichmüller Wöll; Sabine Chwatal; Markus Ritter; Markus Paulmichl
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology     Volume:  12     ISSN:  1015-8987     ISO Abbreviation:  Cell. Physiol. Biochem.     Publication Date:  2002  
Date Detail:
Created Date:  2002-11-19     Completed Date:  2003-06-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9113221     Medline TA:  Cell Physiol Biochem     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  235-58     Citation Subset:  IM    
Copyright Information:
Copyright 2002 S. Karger AG, Basel
Institute of Physiology, University of Innsbruck, Austria.
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MeSH Terms
Arachidonic Acid / pharmacology
Autocrine Communication / physiology
Calcium / metabolism
Cell Membrane / physiology
Cell Size / physiology*
Cytoskeleton / metabolism
Eicosanoids / pharmacology
Inositol Phosphates / metabolism,  pharmacology
Ion Channels / metabolism
Osmosis / physiology
Phosphatidylinositols / metabolism,  pharmacology
Receptors, Purinergic P2 / metabolism
Signal Transduction / physiology*
Reg. No./Substance:
0/Eicosanoids; 0/Inositol Phosphates; 0/Ion Channels; 0/Phosphatidylinositols; 0/Receptors, Purinergic P2; 506-32-1/Arachidonic Acid; 7440-70-2/Calcium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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