Document Detail

Mechanisms of selection and differentiation in germinal centers.
MedLine Citation:
PMID:  9099789     Owner:  NLM     Status:  MEDLINE    
The choice between death and survival, a feature of early B cell development, is a choice also faced by mature B cells. If they survive this early developmental decision, mature B cells then face a second choice: either to undergo either terminal differentiation into plasma cells or to differentiate into memory B cells. Antigens, T cell signals (cytokines, CD40 ligand and Fas ligand) as well as the activation state of B cells determine their ultimate fate.
Y J Liu; O de Bouteiller; I Fugier-Vivier
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current opinion in immunology     Volume:  9     ISSN:  0952-7915     ISO Abbreviation:  Curr. Opin. Immunol.     Publication Date:  1997 Apr 
Date Detail:
Created Date:  1998-04-15     Completed Date:  1998-04-15     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8900118     Medline TA:  Curr Opin Immunol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  256-62     Citation Subset:  IM    
Schering-Plough, Laboratory for Immunological Research, Dardilly, France.
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MeSH Terms
B-Lymphocytes / cytology*,  immunology
Cell Differentiation / genetics,  immunology
Germinal Center / immunology*

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