Document Detail


Mechanisms responsible for countershock-induced ventricular tachycardia in the intact canine heart.
MedLine Citation:
PMID:  3812181     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To determine the mechanism for postcountershock ventricular ectopy, internal and external shocks were delivered to 20 anesthetized dogs. Shock energies of 25 and 50 joules were employed internally while 100 and 200 joules were delivered externally. Experiments were performed in both the presence and absence of a nearly toxic dose of ouabain. All shocks resulted in the occurrence of nonsustained (less than 15 seconds) ventricular tachycardia. When bursts of rapid ventricular pacing were synchronized with a shock, the pacing stimuli invariably captured the ventricles and overdrove the shock-induced ventricular tachycardia. However, the burst pacing never appeared to break a tachycardia, since the termination of pacing was followed immediately by the resumption of the shock-induced ventricular tachycardia. The presence of ouabain did not alter the response of the ventricles to postshock burst pacing. Administration of verapamil (0.5 mg/kg) had no effect on the duration of shock-induced ventricular arrhythmia. Elevation of the serum potassium level to 8.5 +/- 0.6 mEq/L drastically reduced the duration of postshock ventricular tachycardia in both the presence and absence of ouabain. The results suggest that postshock ventricular ectopy results from an abnormality of impulse initiation rather than reentry.
Authors:
F Leja; P J Scanlon; D E Euler
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American heart journal     Volume:  113     ISSN:  0002-8703     ISO Abbreviation:  Am. Heart J.     Publication Date:  1987 Feb 
Date Detail:
Created Date:  1987-03-06     Completed Date:  1987-03-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370465     Medline TA:  Am Heart J     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  296-301     Citation Subset:  AIM; IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Dogs
Electric Countershock / adverse effects*
Hyperkalemia / complications
Ouabain / pharmacology
Tachycardia / etiology*,  physiopathology
Chemical
Reg. No./Substance:
630-60-4/Ouabain

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Acute and chronic effects of amiodarone on delayed afterdepolarization and triggered automaticity in...
Next Document:  Total and unbound concentrations of quinidine and 3-hydroxyquinidine at steady state.