| Mechanisms of reocclusion after coronary thrombolysis. | |
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MedLine Citation:
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PMID: 8328198 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The benefits of coronary thrombolysis appear to depend primarily on achieving and maintaining coronary artery patency. Unfortunately, failure of coronary thrombolysis or recurrent occlusion may occur in up to 40% of patients treated with fibrinolytic agents. Results of recent studies suggest that recurrent thrombosis may be due to multiple factors including: plasmin-mediated activation of the coagulation system, procoagulant activity of the residual thrombus, presence of high shear forces that promote platelet deposition, and attenuation of physiologic fibrinolytic activity after pharmacologic thrombolysis. Preliminary data suggest that recently developed novel anticoagulants and antiplatelet agents may improve the rate of initial recanalization and prevent recurrent thrombus. |
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Authors:
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P R Eisenberg |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
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Title: Zeitschrift für Kardiologie Volume: 82 Suppl 2 ISSN: 0300-5860 ISO Abbreviation: Z Kardiol Publication Date: 1993 |
Date Detail:
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Created Date: 1993-08-09 Completed Date: 1993-08-09 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0360430 Medline TA: Z Kardiol Country: GERMANY |
Other Details:
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Languages: eng Pagination: 175-8 Citation Subset: IM |
Affiliation:
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Washington University School of Medicine, Cardiovascular Division, St. Louis, Missouri. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Blood Coagulation Factors
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physiology Coronary Thrombosis / blood, drug therapy* Humans Myocardial Infarction / blood, drug therapy* Platelet Aggregation / drug effects, physiology Recurrence Thrombolytic Therapy* |
| Grant Support | |
ID/Acronym/Agency:
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HL-17646/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Blood Coagulation Factors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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