Document Detail

Mechanisms of reocclusion after coronary thrombolysis.
MedLine Citation:
PMID:  8328198     Owner:  NLM     Status:  MEDLINE    
The benefits of coronary thrombolysis appear to depend primarily on achieving and maintaining coronary artery patency. Unfortunately, failure of coronary thrombolysis or recurrent occlusion may occur in up to 40% of patients treated with fibrinolytic agents. Results of recent studies suggest that recurrent thrombosis may be due to multiple factors including: plasmin-mediated activation of the coagulation system, procoagulant activity of the residual thrombus, presence of high shear forces that promote platelet deposition, and attenuation of physiologic fibrinolytic activity after pharmacologic thrombolysis. Preliminary data suggest that recently developed novel anticoagulants and antiplatelet agents may improve the rate of initial recanalization and prevent recurrent thrombus.
P R Eisenberg
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Zeitschrift für Kardiologie     Volume:  82 Suppl 2     ISSN:  0300-5860     ISO Abbreviation:  Z Kardiol     Publication Date:  1993  
Date Detail:
Created Date:  1993-08-09     Completed Date:  1993-08-09     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0360430     Medline TA:  Z Kardiol     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  175-8     Citation Subset:  IM    
Washington University School of Medicine, Cardiovascular Division, St. Louis, Missouri.
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MeSH Terms
Blood Coagulation Factors / physiology
Coronary Thrombosis / blood,  drug therapy*
Myocardial Infarction / blood,  drug therapy*
Platelet Aggregation / drug effects,  physiology
Thrombolytic Therapy*
Grant Support
Reg. No./Substance:
0/Blood Coagulation Factors

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