Document Detail


Mechanisms of renal vasodilation and hyperfiltration during pregnancy: current perspectives and potential implications for preeclampsia.
MedLine Citation:
PMID:  16036316     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A thorough understanding of the renal and cardiovascular adaptations to normal gestation is essential for proper diagnosis and management of hypertensive disorders and renal diseases during pregnancy. Here, we briefly review the renal hemodynamic changes of normal pregnancy. In addition, we present new findings and current concepts related to the underlying hormonal and molecular mechanisms. Finally, we speculate on the potential contribution of these insights from normal pregnancy to the pathogenesis of preeclampsia.
Authors:
K P Conrad; J Novak; L A Danielson; L J Kerchner; A Jeyabalan
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Endothelium : journal of endothelial cell research     Volume:  12     ISSN:  1062-3329     ISO Abbreviation:  Endothelium     Publication Date:    2005 Jan-Apr
Date Detail:
Created Date:  2005-07-22     Completed Date:  2005-09-08     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9412590     Medline TA:  Endothelium     Country:  United States    
Other Details:
Languages:  eng     Pagination:  57-62     Citation Subset:  IM    
Affiliation:
Department of Obstetrics/Gynecology, University of Pittsburgh School of Medicine and Magee-Women's Research Institute, Pittsburgh, PA 15213, USA. rsikpc@mwri.magee.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Dilatation, Pathologic
Female
Glomerular Filtration Rate*
Hormones / metabolism
Humans
Kidney / blood supply,  physiopathology*
Pre-Eclampsia / physiopathology*
Pregnancy / physiology*
Vasodilation
Grant Support
ID/Acronym/Agency:
K11 HD00662/HD/NICHD NIH HHS; R01 DK63321/DK/NIDDK NIH HHS; R01 HD30325/HD/NICHD NIH HHS; R01 HL67937/HL/NHLBI NIH HHS; R01HL38076/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Hormones

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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