| Mechanisms regulating dendritic cell specification and development. | |
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MedLine Citation:
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PMID: 20969586 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Understanding the diversification of dendritic cell (DC) lineages is one of the last frontiers in mapping the developmental hierarchy of the hematopoietic system. DCs are a vital link between the innate and adaptive immune responses; thus, elucidating their developmental pathways is crucial for insight into the generation of natural immunity and for learning how to regulate DCs in clinical settings. DCs arise from hematopoietic stem cells through specialized progenitor subsets under the direction of FMS-like tyrosine kinase 3 ligand (Flt3L) and Flt3L receptor (Flt3) signaling. Recent studies have revealed important contributions from granulocyte-macrophage colony-stimulating factor (GM-CSF) and type I interferons (IFNs) in vivo. Furthermore, DC development is guided by lineage-restricted transcription factors such as IRF8, E2-2, and Batf3. A critical question centers on how cytokines and lineage-restricted transcription factors operate molecularly to direct DC diversification. Here, we review recent findings that provide new insight into the DC developmental process. |
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Authors:
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Stephanie S Watowich; Yong-Jun Liu |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Immunological reviews Volume: 238 ISSN: 1600-065X ISO Abbreviation: Immunol. Rev. Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-10-25 Completed Date: 2011-05-10 Revised Date: 2011-11-01 |
Medline Journal Info:
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Nlm Unique ID: 7702118 Medline TA: Immunol Rev Country: Denmark |
Other Details:
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Languages: eng Pagination: 76-92 Citation Subset: IM |
Copyright Information:
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© 2010 John Wiley & Sons A/S. |
Affiliation:
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Department of Immunology and Center for Cancer Immunology Research, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA. swatowic@mdanderson.org |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Differentiation Cell Lineage Dendritic Cells / immunology* Gene Expression Regulation, Developmental / immunology* Granulocyte-Macrophage Colony-Stimulating Factor / immunology Hematopoietic Stem Cells / immunology Humans Immune System / embryology, growth & development Interferon Type I / immunology Membrane Proteins / immunology* Signal Transduction / immunology |
| Grant Support | |
ID/Acronym/Agency:
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AI059718/AI/NIAID NIH HHS; AI073587/AI/NIAID NIH HHS; AR059010/AR/NIAMS NIH HHS; P30CA16672/CA/NCI NIH HHS; R21 AI073587-02/AI/NIAID NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Interferon Type I; 0/Membrane Proteins; 0/flt3 ligand protein; 83869-56-1/Granulocyte-Macrophage Colony-Stimulating Factor |
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