| Mechanisms of photoinduced electron transfer reactions of lappaconitine with aromatic amino acids. Time-resolved CIDNP study. | |
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MedLine Citation:
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PMID: 15731875 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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CIDNP techniques were applied to the investigation of the elementary mechanism of photoinduced interaction between anti-arrhythmic drug lappaconitine and amino acids tyrosine and tryptophan. It has been shown that the reactions involve the formation of lappaconitine radical anion. Lappaconitine radical anion is unstable and rapidly eliminates N-acetyl anthranilic acid via protonation and ether bond cleavage. The rate constant of ether bond cleavage was estimated to be equal to 4 x 10(5) s(-1). The role of single electron transfer is discussed in the light of the model of drug-receptor interactions. |
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Authors:
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Nikolai E Polyakov; Vladimir K Khan; Marc B Taraban; Tatyana V Leshina; Olga A Luzina; Nariman F Salakhutdinov; Genrikh A Tolstikov |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2005-02-04 |
Journal Detail:
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Title: Organic & biomolecular chemistry Volume: 3 ISSN: 1477-0520 ISO Abbreviation: Org. Biomol. Chem. Publication Date: 2005 Mar |
Date Detail:
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Created Date: 2005-02-25 Completed Date: 2006-06-22 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 101154995 Medline TA: Org Biomol Chem Country: England |
Other Details:
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Languages: eng Pagination: 881-5 Citation Subset: IM |
Affiliation:
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Institute of Chemical Kinetics and Combustion, Novosibirsk-90, 630090, Russia. polyakov@ns.kinetics.nsc.ru |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aconitine
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analogs & derivatives*,
chemistry Amino Acids, Aromatic / chemistry* Anthranilic Acids / chemistry Anti-Arrhythmia Agents / chemistry Electron Transport Free Radicals / chemistry Ions / chemistry Magnetic Resonance Spectroscopy* Molecular Structure Photochemistry Protons Tryptophan / chemistry Tyrosine / chemistry |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids, Aromatic; 0/Anthranilic Acids; 0/Anti-Arrhythmia Agents; 0/Free Radicals; 0/Ions; 0/Protons; 302-27-2/Aconitine; 32854-75-4/lappaconitine; 55520-40-6/Tyrosine; 73-22-3/Tryptophan; 89-52-1/N-acetylanthranilic acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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