| Mechanisms of nutritional and hormonal regulation of lipogenesis. | |
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MedLine Citation:
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PMID: 11306547 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Fat build-up is determined by the balance between lipogenesis and lipolysis/fatty acid oxidation. In the past few years, our understanding of the nutritional, hormonal and particularly transcriptional regulation of lipogenesis has expanded greatly. Lipogenesis is stimulated by a high carbohydrate diet, whereas it is inhibited by polyunsaturated fatty acids and by fasting. These effects are partly mediated by hormones, which inhibit (growth hormone, leptin) or stimulate (insulin) lipogenesis. Recent research has established that sterol regulatory element binding protein-1 is a critical intermediate in the pro- or anti-lipogenic action of several hormones and nutrients. Another transcription factor implicated in lipogenesis is the peroxisome proliferator activated receptor gamma. Both transcription factors are attractive targets for pharmaceutical intervention of disorders such as hypertriglyceridemia and obesity. |
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Authors:
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S Kersten |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: EMBO reports Volume: 2 ISSN: 1469-221X ISO Abbreviation: EMBO Rep. Publication Date: 2001 Apr |
Date Detail:
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Created Date: 2001-04-18 Completed Date: 2001-08-02 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 100963049 Medline TA: EMBO Rep Country: England |
Other Details:
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Languages: eng Pagination: 282-6 Citation Subset: IM |
Affiliation:
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Nutrition, Metabolism and Genomics Group, Wageningen University, PO Box 8129, 6700 EV Wageningen, The Netherlands. sander.kersten@staff.nutepi.wau.nl |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adipocytes
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physiology Animals CCAAT-Enhancer-Binding Proteins / metabolism DNA-Binding Proteins / metabolism Diet Fatty Acids / metabolism Hepatocytes / physiology Humans Lipids / physiology* Models, Biological Receptors, Cytoplasmic and Nuclear / metabolism Sterol Regulatory Element Binding Protein 1 Transcription Factors / metabolism Transcription, Genetic |
| Chemical | |
Reg. No./Substance:
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0/CCAAT-Enhancer-Binding Proteins; 0/DNA-Binding Proteins; 0/Fatty Acids; 0/Lipids; 0/Receptors, Cytoplasmic and Nuclear; 0/SREBF1 protein, human; 0/Sterol Regulatory Element Binding Protein 1; 0/Transcription Factors |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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