Document Detail

Mechanisms of nutritional and hormonal regulation of lipogenesis.
MedLine Citation:
PMID:  11306547     Owner:  NLM     Status:  MEDLINE    
Fat build-up is determined by the balance between lipogenesis and lipolysis/fatty acid oxidation. In the past few years, our understanding of the nutritional, hormonal and particularly transcriptional regulation of lipogenesis has expanded greatly. Lipogenesis is stimulated by a high carbohydrate diet, whereas it is inhibited by polyunsaturated fatty acids and by fasting. These effects are partly mediated by hormones, which inhibit (growth hormone, leptin) or stimulate (insulin) lipogenesis. Recent research has established that sterol regulatory element binding protein-1 is a critical intermediate in the pro- or anti-lipogenic action of several hormones and nutrients. Another transcription factor implicated in lipogenesis is the peroxisome proliferator activated receptor gamma. Both transcription factors are attractive targets for pharmaceutical intervention of disorders such as hypertriglyceridemia and obesity.
S Kersten
Related Documents :
2408687 - In vivo effects of follicle-stimulating hormone on testicular macrophages.
8392377 - Polyunsaturated fatty acids in heart muscle and alpha 1-adrenoceptor binding properties.
3329407 - Nonesterified fatty acids: role in the molecular events linking endocrinology and oncol...
17118457 - D-aspartic acid: an endogenous amino acid with an important neuroendocrine role.
11038307 - Uptake and interconversion of fluorescent lipid analogs in the protozoan parasite, perk...
22706677 - Differences between group x and group v secretory phospholipase a(2) in lipolytic modif...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  EMBO reports     Volume:  2     ISSN:  1469-221X     ISO Abbreviation:  EMBO Rep.     Publication Date:  2001 Apr 
Date Detail:
Created Date:  2001-04-18     Completed Date:  2001-08-02     Revised Date:  2013-06-11    
Medline Journal Info:
Nlm Unique ID:  100963049     Medline TA:  EMBO Rep     Country:  England    
Other Details:
Languages:  eng     Pagination:  282-6     Citation Subset:  IM    
Nutrition, Metabolism and Genomics Group, Wageningen University, PO Box 8129, 6700 EV Wageningen, The Netherlands.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Adipocytes / physiology
CCAAT-Enhancer-Binding Proteins / metabolism
DNA-Binding Proteins / metabolism
Fatty Acids / metabolism
Hepatocytes / physiology
Lipids / physiology*
Models, Biological
Receptors, Cytoplasmic and Nuclear / metabolism
Sterol Regulatory Element Binding Protein 1
Transcription Factors / metabolism
Transcription, Genetic
Reg. No./Substance:
0/CCAAT-Enhancer-Binding Proteins; 0/DNA-Binding Proteins; 0/Fatty Acids; 0/Lipids; 0/Receptors, Cytoplasmic and Nuclear; 0/SREBF1 protein, human; 0/Sterol Regulatory Element Binding Protein 1; 0/Transcription Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Cell migration: GAPs between membrane traffic and the cytoskeleton.
Next Document:  Homologous recombination in planta is stimulated in the absence of Rad50.