Document Detail

Mechanisms of neurohormonal activation in chronic congestive heart failure: pathophysiology and therapeutic implications.
MedLine Citation:
PMID:  15907399     Owner:  NLM     Status:  MEDLINE    
Patients with chronic congestive heart failure have a sequential and incessant activation of those neurohormonal systems, which control body fluids, cardiac output and systemic blood pressure. Neurohormonal activation is initially selective and regional. Generalized activation is a late event in the natural history of congestive heart failure. Although the ultimate stimulus responsible for the activation of these neurohormonal systems is unknown, a decreased cardiac output and diminished effective blood volume have been proposed as the responsible mechanisms. However, extensive clinical and experimental research suggest that cardiac remodeling and loading of low-pressure cardiac receptors with sympathetic afferents could be the triggering events followed by unloading of high-pressure carotid receptors by decreased cardiac output and diminished effective blood volume.
Diego F Dávila; Tulio J Núñez; Rodolfo Odreman; Carmen A Mazzei de Dávila
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  International journal of cardiology     Volume:  101     ISSN:  0167-5273     ISO Abbreviation:  Int. J. Cardiol.     Publication Date:  2005 Jun 
Date Detail:
Created Date:  2005-05-23     Completed Date:  2005-09-13     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8200291     Medline TA:  Int J Cardiol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  343-6     Citation Subset:  IM    
Instituto de Investigaciones Cardiovasculares, Universidad de Los Andes, Mérida, Venezuela.
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MeSH Terms
Adrenergic beta-Antagonists / therapeutic use*
Cardiotonic Agents / therapeutic use*
Heart Failure / drug therapy*,  metabolism,  physiopathology*
Heart Ventricles / innervation,  physiopathology
Hormones / physiology*
Neurotransmitter Agents / physiology*
Signal Transduction / drug effects,  physiology
Sympathetic Nervous System / metabolism,  physiopathology
Vasodilator Agents / therapeutic use*
Reg. No./Substance:
0/Adrenergic beta-Antagonists; 0/Cardiotonic Agents; 0/Hormones; 0/Neurotransmitter Agents; 0/Vasodilator Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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