Document Detail

Mechanisms of disease/hypothesis: neurogenic left ventricular dysfunction and neurogenic pulmonary oedema.
MedLine Citation:
PMID:  19652941     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Acute onset of cardiovascular dysfunction may be the result of insults to the central nervous and autonomic system. Several cerebral regions (insular cortex, lateral, hypothalamus, and brain stem) have been identified as part of the "central autonomic network". The brain stem plays an integral role in controlling and mediating autonomic tone. PATIENT AND METHODS: Case reports. RESULTS: These two case reports demonstrate the intimate connectivity between the cardiovascular/pulmonary system and the central nervous system in a 13-year-old girl with occipital angiomatosis, but no history of heart disease who developed profound left ventricular dysfunction and pulmonary oedema following pontine haemorrhage, and in a 5-year-old girl who developed severe pulmonary oedema after suffering from status epilepticus. CONCLUSIONS: The two case reports suggest that cardiovascular dysfunction secondary to central nervous insults and neurogenic pulmonary oedema are not two separate clinical entities, but may very well encompass two different presentations of central autonomic disturbances.
Sascha Meyer; Angelika Lindinger; G?nther L?ffler; Hans-Gerhard Limbach; Mohammed G Shamdeen; Sven Gottschling; Wolfgang Reith; Ludwig Gortner
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Wiener medizinische Wochenschrift (1946)     Volume:  159     ISSN:  1563-258X     ISO Abbreviation:  Wien Med Wochenschr     Publication Date:  2009  
Date Detail:
Created Date:  2009-08-04     Completed Date:  2009-11-16     Revised Date:  2010-04-05    
Medline Journal Info:
Nlm Unique ID:  8708475     Medline TA:  Wien Med Wochenschr     Country:  Austria    
Other Details:
Languages:  eng     Pagination:  342-5     Citation Subset:  IM    
Department of Paediatric Intensive Care Medicine and Neonatology, University Hospital of Saarland, Homburg, Germany.
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MeSH Terms
Autonomic Nervous System / physiopathology*
Brain / physiopathology*
Brain Stem / blood supply,  physiopathology
Cardiac Output, Low / physiopathology,  therapy
Cerebral Angiography
Child, Preschool
Heart / innervation
Intracranial Arteriovenous Malformations / physiopathology
Intracranial Hemorrhages / physiopathology,  therapy
Magnetic Resonance Imaging
Nerve Net
Occipital Lobe / blood supply,  physiopathology
Pulmonary Edema / physiopathology*,  therapy
Status Epilepticus / physiopathology,  therapy
Ventricular Dysfunction, Left / physiopathology*,  therapy
Comment In:
Wien Med Wochenschr. 2010 Mar;160(5-6):152-4   [PMID:  20364419 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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