Document Detail

Mechanisms of neonatal increase in glomerular filtration rate.
MedLine Citation:
PMID:  18635454     Owner:  NLM     Status:  MEDLINE    
To investigate the mechanisms responsible for the neonatal increase in glomerular filtration rate (GFR), renal function studies (whole kidney and micropuncture) were carried out in anesthesized fetal sheep (133-140 days gestation; term = 150 days) and lambs (12-18 days). Fetuses were delivered and placed in a water bath (39.5 degrees C), keeping the umbilical cord moist and intact. Lambs were studied on a thermostatically controlled heating pad. Animals were prepared for either blood flow studies or micropuncture measurements. Expected differences in blood composition and cardiovascular and renal function were observed between fetuses and lambs, and values obtained for most variables were similar to those measured in chronically catheterized unanesthetized animals. Fetal GFR was much lower than that of lambs (0.20 vs. 0.62 ml.min(-1).g kidney(-1), P < 0.001). Free-flow, stop-flow, and net filtration pressures (NFP) were lower in the fetuses than the lambs (NFP 20.8 vs. 23.8 mmHg, P < 0.001), as was the calculated ultrafiltration coefficient (0.014 vs. 0.022 ml.min(-1).g(-1).mmHg(-1), P < 0.001). Thus, we conclude that rises in both net filtration pressure and the ultrafiltration coefficient contribute to the large increase in GFR between fetal life and approximately 2 wk after birth.
Anita J Turner; Russell D Brown; Mattias Carlström; Karen J Gibson; A Erik G Persson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-07-16
Journal Detail:
Title:  American journal of physiology. Regulatory, integrative and comparative physiology     Volume:  295     ISSN:  0363-6119     ISO Abbreviation:  Am. J. Physiol. Regul. Integr. Comp. Physiol.     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-09-08     Completed Date:  2008-10-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100901230     Medline TA:  Am J Physiol Regul Integr Comp Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  R916-21     Citation Subset:  IM    
Dept. of Physiology, School of Medical Sciences, Univ. of New South Wales, Sydney, 2052, Australia.
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MeSH Terms
Animals, Newborn
Blood Pressure / physiology
Carbon Dioxide / blood
Gestational Age
Glomerular Filtration Rate / physiology*
Heart Rate / physiology
Hydrogen-Ion Concentration
Hydrostatic Pressure
Kidney / cytology,  embryology*,  physiology*
Nephrons / cytology
Oxygen / blood
Sodium / urine
Reg. No./Substance:
124-38-9/Carbon Dioxide; 7440-23-5/Sodium; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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