Document Detail

Mechanisms of myocardial infarction without obstructive coronary artery disease.
MedLine Citation:
PMID:  24444810     Owner:  NLM     Status:  Publisher    
Angiography in patients with myocardial infarction (MI) most commonly reveals one or more significantly narrowed coronary arteries, but a substantial minority of patients with spontaneous MI have no obstructive coronary artery disease (CAD) at angiography. This review summarizes evidence for the most commonly hypothesized mechanisms, including plaque disruption, plaque erosion, vasospasm, embolism, and spontaneous coronary dissection. In addition, tako-tsubo syndrome and myocarditis are discussed. The best treatment of MI without obstructive CAD is likely to differ substantially based on the underlying cause. Additional mechanistic research is needed to facilitate the design of research studies aimed at documenting the best treatments for these patients, numbering as many as 225,000 per year in the US.
Harmony R Reynolds
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-12-14
Journal Detail:
Title:  Trends in cardiovascular medicine     Volume:  -     ISSN:  1873-2615     ISO Abbreviation:  Trends Cardiovasc. Med.     Publication Date:  2013 Dec 
Date Detail:
Created Date:  2014-1-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9108337     Medline TA:  Trends Cardiovasc Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2014 Elsevier Inc. All rights reserved.
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