Document Detail

Mechanisms for muscle health in the critically ill patient.
MedLine Citation:
PMID:  23221437     Owner:  NLM     Status:  In-Data-Review    
Human skeletal muscles are continually remodeled to match the function required of them. Diameter, strength, and vascular supply are altered when a muscle group experiences contraction and resistance. The purpose of this article is to describe selected muscle signaling pathways that contribute to muscle remodeling. Multiple factors affect the cellular and molecular remodeling of muscles and at least 2 of them-exercise and protein/calorie delivery-are under the direct care of intensive care unit (ICU) clinicians. Activating signaling pathways may promote preservation of muscle mass and function. Interventions to prevent muscle atrophy have potential to reduce ICU-acquired weakness and positively affect quality of life in survivors after ICU hospitalization. Exploring information generated by genomic and proteomic investigations about muscle signaling pathways can help the ICU clinician evaluate the benefits and risks of interventions to maintain muscle health early in critical illness.
Chris Winkelman
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Critical care nursing quarterly     Volume:  36     ISSN:  1550-5111     ISO Abbreviation:  Crit Care Nurs Q     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2012-12-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8704517     Medline TA:  Crit Care Nurs Q     Country:  United States    
Other Details:
Languages:  eng     Pagination:  5-16     Citation Subset:  N    
Frances Payne Bolton School of Nursing, Case Western Reserve University, and MetroHealth Medical Center, Cleveland Ohio.
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