Document Detail


Mechanisms mediating nutritional effects on embryonic survival in pigs.
MedLine Citation:
PMID:  9602719     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The inconsistency of data from experiments designed to show nutritional effects on embryonic survival is perplexing. However, a number of experimental models have provided some insight into the mechanisms that potentially mediate interactions between nutrition, metabolic state and embryonic survival. The developing ovarian follicle provides the maturational environment for the oocyte, and differences in follicular maturation are associated with differences in the ability of these follicles to support oocyte maturation. In turn, the rate of oocyte maturation and the maturational state of the oocyte immediately before ovulation may contribute to differences in embryonic survival. Therefore, evidence that nutritionally induced differences in metabolic state affect follicular development and the maturational state of the oocyte in the late follicular phase may constitute a mechanism by which nutrition affects the very early stages of conceptus development. Once ovulation occurs, the process of fertilization and early cleavage occurs in the environment of the oviduct. Nutritional state might affect the secretory and motile activity of the oviduct both directly, by influencing the physiology of the oviductal cells, or indirectly by affecting the secretion of key regulatory hormones. Thus evidence for nutritionally dependent effects on plasma progesterone concentrations in early pregnancy and associations with differences in embryonic survival may be partly mediated at the oviductal stage of development. Nutritional effects on circulating progesterone concentrations may also affect the uterine environment. However, the metabolic state of the gilt or sow, or specific nutrients in the diet, may directly affect the integrity of the endometrium and thus affect embryonic survival at this stage of development.
Authors:
G R Foxcroft
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Journal of reproduction and fertility. Supplement     Volume:  52     ISSN:  0449-3087     ISO Abbreviation:  J. Reprod. Fertil. Suppl.     Publication Date:  1997  
Date Detail:
Created Date:  1998-06-09     Completed Date:  1998-06-09     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0225652     Medline TA:  J Reprod Fertil Suppl     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  47-61     Citation Subset:  IM    
Affiliation:
Alberta Pork Research Centre, Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Canada.
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MeSH Terms
Descriptor/Qualifier:
Animal Nutritional Physiological Phenomena*
Animals
Fallopian Tubes / physiology
Female
Fetal Death*
Insulin / metabolism
Luteinizing Hormone / secretion
Oogenesis / physiology
Ovarian Follicle / physiology
Pregnancy
Pregnancy, Animal / metabolism*
Progesterone / blood
Swine / metabolism*
Chemical
Reg. No./Substance:
11061-68-0/Insulin; 57-83-0/Progesterone; 9002-67-9/Luteinizing Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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