Document Detail

Mechanisms mediating the coronary vascular response to behavioral stress in the dog.
MedLine Citation:
PMID:  6109579     Owner:  NLM     Status:  MEDLINE    
Left circumflex coronary blood flow (CBF) was measured in eight mongrel dogs with 8 MHz continuous wave Doppler flow transducers during classical aversive conditioning. The cardiovascular condition response consisted of significant (P less than 0.01) increases in: (1) mean aortic pressure (16.1%), (2) d(left ventricular pressure)/dt (64.2%), and (3) heart rate (63.2%). The coronary vascular response to behavioral stress consisted of an initial late diastolic decrease in CBF (12.5%) between 5 and 10 seconds after conditional stimulus onset, followed by a significant increase in CBF (96.8%). Concurrently, late diastolic coronary vascular resistance (CVR) first significantly increased (21.9%), then significantly decreased (39.8%). The increase in CVR was attenuated by cardiac pacing and converted into a significant decrease after alpha-receptor blockade. The decrease in CVR was reduced either by cardiac pacing or cardioselective beta-receptor blockage and eliminated by the combination of alpha- and beta-receptor blockade. Thus, these data indicate that the coronary vascular response to stress consisted of two components: an initial alpha-adrenergic coronary vasoconstriction, followed by a more complex vasodilation which was probably mediated by metabolites released secondarily to increases in heart rate and inotropic state.
G E Billman; D C Randall
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Circulation research     Volume:  48     ISSN:  0009-7330     ISO Abbreviation:  Circ. Res.     Publication Date:  1981 Feb 
Date Detail:
Created Date:  1981-04-21     Completed Date:  1981-04-21     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0047103     Medline TA:  Circ Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  214-23     Citation Subset:  IM    
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MeSH Terms
Adrenergic alpha-Antagonists / pharmacology
Adrenergic beta-Antagonists / pharmacology
Blood Pressure
Cardiac Pacing, Artificial
Conditioning, Classical / physiology
Coronary Circulation*
Coronary Vessels / physiology
Heart Rate
Metoprolol / pharmacology
Stress, Psychological / physiopathology*
Vascular Resistance
Grant Support
Reg. No./Substance:
0/Adrenergic alpha-Antagonists; 0/Adrenergic beta-Antagonists; 37350-58-6/Metoprolol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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