Document Detail

Mechanisms of lymphocyte migration in autoimmune disease.
MedLine Citation:
PMID:  16101827     Owner:  NLM     Status:  MEDLINE    
The recruitment of leukocytes to inflamed tissues plays an essential role in combating infection and promoting wound healing. However, in autoimmune diseases such as multiple sclerosis and diabetes, leukocytes enter tissues and contribute to inappropriate inflammatory responses, which cause tissue injury and dysfunction. In diseases of this type, lymphocytes play critical roles in initiating and maintaining these aberrant inflammatory responses. The aim of this review is to examine the mechanisms whereby T-lymphocytes enter tissues in autoimmune diseases and to compare these mechanisms between various organs and diseases. An overview of the mechanisms of leukocyte recruitment and the techniques used to study leukocyte trafficking is provided, focusing on the use of intravital microscopy as a tool to assess the functional microvasculature in vivo. We also discuss the series of tissue homing events which allow naïve lymphocytes to first enter lymph nodes and undergo activation, then subsequently to home to the peripheral organ where their cognate antigen is present. Finally, we examine mechanisms of leukocyte recruitment in diseases such as multiple sclerosis, autoimmune diabetes, systemic lupus erythematosus, rheumatoid arthritis, inflammatory bowel disease and asthma.
M U Norman; M J Hickey
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Tissue antigens     Volume:  66     ISSN:  0001-2815     ISO Abbreviation:  Tissue Antigens     Publication Date:  2005 Sep 
Date Detail:
Created Date:  2005-08-16     Completed Date:  2005-12-28     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0331072     Medline TA:  Tissue Antigens     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  163-72     Citation Subset:  IM    
Immunology Research Group, University of Calgary, Calgary, AB, Canada.
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MeSH Terms
Asthma / blood
Autoimmune Diseases / blood*
Cell Movement
Diabetes Mellitus, Type 1 / blood
Inflammatory Bowel Diseases / blood
Lupus Erythematosus, Systemic / blood
Lymph Nodes / pathology
Lymphocytes / cytology*
Microscopy, Fluorescence
Models, Biological
Multiple Sclerosis / blood
Grant Support

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