Document Detail

Mechanisms of the "low-flow" state during resuscitation of the totally ischemic brain.
MedLine Citation:
PMID:  837260     Owner:  NLM     Status:  MEDLINE    
Resuscitation of the brain following total circulatory arrest may be impeded by difficulty in establishing cerebral tissue perfusion, a postischemic "low-flow"state. We have confirmed this hypothesis in a rat model of total cerebral ischemia and have demonstrated marked imporvement in post-ischemic brain tissue perfusion following epinephrine injection. This is mainly due to the systemic vascular effects of epinephrine, resulting in improved central arotic pressure and cerebral perfusion pressure. Hyperkalemic induced vasoconstriction has also been postulated as a cause of the "low-flow/. We have, therefore, investigated the in vitro effects of increasing potassium ion concentration on cerebrovascular smooth muscle strips. Large arteries constrict, while small arteries dilate in response to hyperkalemia. The net effect on cerebral blood flow remains unsettled. Our research to date suggests that resuscitation of the totally ischemic brain, in animal models at least, is enhanced by epinephrine, mainly via its effects on central aortic pressure.
W A Tweed; J G Wade; W J Davidson
Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques     Volume:  4     ISSN:  0317-1671     ISO Abbreviation:  Can J Neurol Sci     Publication Date:  1977 Feb 
Date Detail:
Created Date:  1977-04-15     Completed Date:  1977-04-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0415227     Medline TA:  Can J Neurol Sci     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  19-23     Citation Subset:  IM    
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MeSH Terms
Blood Pressure
Brain / blood supply*
Cerebral Arteries / drug effects
Cerebrovascular Circulation / drug effects*
Epinephrine / pharmacology*
Heart Arrest / physiopathology*
Ischemia / physiopathology*
Muscle, Smooth / drug effects
Potassium / pharmacology
Resuscitation* / methods*
Reg. No./Substance:
51-43-4/Epinephrine; 7440-09-7/Potassium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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