Document Detail


Mechanisms of liver development: concepts for understanding liver disorders and design of novel therapies.
MedLine Citation:
PMID:  19328801     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The study of liver development has significantly contributed to developmental concepts about morphogenesis and differentiation of other organs. Knowledge of the mechanisms that regulate hepatic epithelial cell differentiation has been essential in creating efficient cell culture protocols for programmed differentiation of stem cells to hepatocytes as well as developing cell transplantation therapies. Such knowledge also provides a basis for the understanding of human congenital diseases. Importantly, much of our understanding of organ development has arisen from analyses of patients with liver deficiencies. We review how the liver develops in the embryo and discuss the concepts that operate during this process. We focus on the mechanisms that control the differentiation and organization of the hepatocytes and cholangiocytes and refer to other reviews for the development of nonepithelial tissue in the liver. Much progress in the characterization of liver development has been the result of genetic studies of human diseases; gaining a better understanding of these mechanisms could lead to new therapeutic approaches for patients with liver disorders.
Authors:
Frédéric P Lemaigre
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2009-03-27
Journal Detail:
Title:  Gastroenterology     Volume:  137     ISSN:  1528-0012     ISO Abbreviation:  Gastroenterology     Publication Date:  2009 Jul 
Date Detail:
Created Date:  2009-06-30     Completed Date:  2009-07-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0374630     Medline TA:  Gastroenterology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  62-79     Citation Subset:  AIM; IM    
Affiliation:
de Duve Institute, Université Catholique de Louvain, Brussels, Belgium. frederic.lemaigre@uclouvain.be
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MeSH Terms
Descriptor/Qualifier:
Animals
Biliary Tract / embryology,  metabolism*
Cell Adhesion
Cell Differentiation
Cell Lineage
Cell Movement
Cell Proliferation
Cell Survival
Endoderm / metabolism
Gene Expression Regulation, Developmental
Hepatocytes / metabolism*
Humans
Liver / embryology,  metabolism*
Liver Diseases / embryology,  genetics,  metabolism*,  therapy
Morphogenesis
Signal Transduction* / genetics
Transcription, Genetic

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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