Document Detail


Mechanisms linking obesity to insulin resistance and type 2 diabetes.
MedLine Citation:
PMID:  17167471     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Obesity is associated with an increased risk of developing insulin resistance and type 2 diabetes. In obese individuals, adipose tissue releases increased amounts of non-esterified fatty acids, glycerol, hormones, pro-inflammatory cytokines and other factors that are involved in the development of insulin resistance. When insulin resistance is accompanied by dysfunction of pancreatic islet beta-cells - the cells that release insulin - failure to control blood glucose levels results. Abnormalities in beta-cell function are therefore critical in defining the risk and development of type 2 diabetes. This knowledge is fostering exploration of the molecular and genetic basis of the disease and new approaches to its treatment and prevention.
Authors:
Steven E Kahn; Rebecca L Hull; Kristina M Utzschneider
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review    
Journal Detail:
Title:  Nature     Volume:  444     ISSN:  1476-4687     ISO Abbreviation:  Nature     Publication Date:  2006 Dec 
Date Detail:
Created Date:  2006-12-14     Completed Date:  2007-01-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0410462     Medline TA:  Nature     Country:  England    
Other Details:
Languages:  eng     Pagination:  840-6     Citation Subset:  IM    
Affiliation:
Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, VA Puget Sound Health Care System and University of Washington, 1660 South Columbian Way, Seattle, Washington 98108, USA. skahn@u.washington.edu
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MeSH Terms
Descriptor/Qualifier:
Diabetes Mellitus, Type 2 / etiology,  genetics,  pathology,  physiopathology*
Humans
Insulin Resistance* / genetics
Islets of Langerhans / pathology,  physiopathology
Obesity / complications,  genetics,  physiopathology*

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