Document Detail

Mechanisms for isolated volume response to a bronchodilator in patients with COPD.
MedLine Citation:
PMID:  10846010     Owner:  NLM     Status:  MEDLINE    
We hypothesized that an altered effect of lung inflation on airway caliber may in part explain the isolated volume response to bronchodilators, i.e., an increase of forced vital capacity (FVC) without change in 1-s forced expiratory volume (FEV(1)). Small-airway caliber was measured by high-resolution computed tomography at functional residual capacity and total lung capacity in five chronic obstructive pulmonary disease patients with an isolated increase of FVC (FVC responders) and five with an increase of both FVC and FEV(1) (FVC-FEV(1) responders) after inhalation of salbutamol. In FVC-FEV(1) responders, the airway diameter increased with the cube root of increase in lung volume but was unchanged or even decreased in four of five FVC responders. FVC responders had more severe emphysema, as inferred from lung function and imaging studies, than FVC-FEV(1) responders. We speculate that longitudinal traction or space competition (Verbeken EK, Cauberghs M, and Van de Woestijne KP, J Appl Physiol 81: 2468-2480, 1996) are possible underlying mechanisms. We conclude that the isolated volume response to bronchodilators is associated with severe emphysema and likely results from an altered effect of lung inflation on airway caliber.
I Cerveri; R Pellegrino; R Dore; A Corsico; P Fulgoni; K P van de Woestijne; V Brusasco
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  88     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  2000 Jun 
Date Detail:
Created Date:  2000-07-12     Completed Date:  2000-07-12     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1989-95     Citation Subset:  IM    
Clinica di Malattie dell' Apparato Respiratorio and Istituto di Radiologia Medica, Istituo di Recovero e Cura a Carattere Scientifico, Pavia, Italy.
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MeSH Terms
Administration, Inhalation
Bronchodilator Agents / therapeutic use*
Forced Expiratory Volume
Functional Residual Capacity
Lung / physiopathology*,  radiography
Lung Diseases, Obstructive / drug therapy*,  physiopathology*,  radiography
Lung Volume Measurements
Middle Aged
Radiography, Thoracic
Tomography, X-Ray Computed
Total Lung Capacity
Vital Capacity
Reg. No./Substance:
0/Bronchodilator Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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