| Mechanisms of ischemic injury in the heart. | |
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MedLine Citation:
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PMID: 3904719 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cardiac ischemia is characterized by rapid deterioration of cardiac function, which has been linked to the fall in intracellular pH, increased levels of inorganic phosphate and reduction in free energy change of ATP-hydrolysis. Biochemical events responsible for irreversible myocardial injury involve various mechanisms which change the properties of the cardiac cell membrane (disorders in lipid metabolism, free radical formation). Recent evidence suggests that in the heart, xanthine oxidase is a major source of free radical formation. During ischemia, adenine-nucleotide breakdown in the cardiomyocyte proceeds only to the stage of inosine. Due to the localisation of nucleoside phosphorylase and xanthine-oxidase in vascular endothelium, further degradation of inosine to hypoxanthine, xanthine and uric acid occurs predominantly in the vascular space. It is therefore conceivable that the primary site of reperfusion injury in the ischemic heart may be the coronary endothelium damaged by free radicals. |
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Authors:
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J Schrader |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Basic research in cardiology Volume: 80 Suppl 2 ISSN: 0300-8428 ISO Abbreviation: Basic Res. Cardiol. Publication Date: 1985 |
Date Detail:
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Created Date: 1985-11-26 Completed Date: 1985-11-26 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0360342 Medline TA: Basic Res Cardiol Country: GERMANY, WEST |
Other Details:
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Languages: eng Pagination: 135-9 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenosine Triphosphate
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metabolism Animals Coronary Disease / metabolism, physiopathology* Free Radicals Heart / physiopathology* Hydrogen-Ion Concentration Myocardial Contraction Myocardium / metabolism, pathology* Oxygen / metabolism Sarcolemma / metabolism, pathology Xanthine Oxidase / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Free Radicals; 56-65-5/Adenosine Triphosphate; 7782-44-7/Oxygen; EC 1.17.3.2/Xanthine Oxidase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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