Document Detail


Mechanisms involved in injury and repair of the murine lacrimal gland: role of programmed cell death and mesenchymal stem cells.
MedLine Citation:
PMID:  20427009     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The non-keratinized epithelia of the ocular surface are constantly challenged by environmental insults, such as smoke, dust, and airborne pathogens. Tears are the sole physical protective barrier for the ocular surface. Production of tears in inadequate quantity or of inadequate quality results in constant irritation of the ocular surface, leading to dry eye disease, also referred to as keratoconjunctivitis sicca (KCS). Inflammation of the lacrimal gland, such as occurs in Sjogren syndrome, sarcoidosis, chronic graft-versus-host disease, and other pathological conditions, results in inadequate secretion of the aqueous layer of the tear film and is a leading cause of dry eye disease. The hallmarks of lacrimal gland inflammation are the presence of immune cell infiltrates, loss of acinar epithelial cells (the secreting cells), and increased production of proinflammatory cytokines. To date, the mechanisms leading to acinar cell loss and the associated decline in lacrimal gland secretion are still poorly understood. It is also not understood why the remaining lacrimal gland cells are unable to proliferate in order to regenerate a functioning lacrimal gland. This article reviews recent advances in exocrine tissue injury and repair, with emphasis on the roles of programmed cell death and stem/progenitor cells.
Authors:
Driss Zoukhri
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  The ocular surface     Volume:  8     ISSN:  1542-0124     ISO Abbreviation:  Ocul Surf     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-04-29     Completed Date:  2010-06-03     Revised Date:  2014-09-15    
Medline Journal Info:
Nlm Unique ID:  101156063     Medline TA:  Ocul Surf     Country:  United States    
Other Details:
Languages:  eng     Pagination:  60-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Apoptosis*
Autophagy*
Dacryocystitis / physiopathology
Lacrimal Apparatus / injuries*,  physiopathology*
Mesenchymal Stromal Cells / physiology*
Mice
Sjogren's Syndrome / physiopathology
Wound Healing*
Grant Support
ID/Acronym/Agency:
R01 EY012383/EY/NEI NIH HHS; R01 EY012383-09A2/EY/NEI NIH HHS; R01 EY012383-10/EY/NEI NIH HHS; R01-EY12383/EY/NEI NIH HHS
Comments/Corrections
Erratum In:
Ocul Surf. 2010 Jul;8(3):134

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