| Mechanisms involved in the expansion of Tregs during pregnancy: role of IL-2/STAT5 signalling. | |
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MedLine Citation:
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PMID: 21329987 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Several studies have reported that the fine-tuning of regulatory T cells (Tregs) is required for a successful pregnancy and for the control of autoimmune diseases. Here, we review the mechanisms that control the expansion of Tregs, based on insights obtained from the study of women suffering unsuccessful pregnancies and on recent data from patients with autoimmune diseases or with chronic viral infections such as HCV. In particular, we review the role of endocrine factors and IL-2/STAT5 signalling in the impaired expansion of Tregs. |
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Authors:
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L Fainboim; L Arruvito |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-2-15 |
Journal Detail:
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Title: Journal of reproductive immunology Volume: - ISSN: 1872-7603 ISO Abbreviation: - Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-2-18 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8001906 Medline TA: J Reprod Immunol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011. Published by Elsevier Ireland Ltd. |
Affiliation:
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Immunogenetics Laboratory, Clinical Hospital, "José de San Martín", Buenos Aires, Argentina; National Council for Scientific and Technological Research (CONICET), Buenos Aires, Argentina; Department of Microbiology, Parasitology and Immunology, School of Medicine, University of Buenos Aires, Buenos Aires, Argentina. |
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