| Mechanisms involved in the cardiovascular alterations immediately after spinal cord injury. | |
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MedLine Citation:
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PMID: 11253169 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The early cardiovascular effects resulting from an acute spinal cord injury (SCI) produced by a contusion procedure at T5-T6 were evaluated in anaesthetized rats. The mean arterial pressure (MAP) and heart rate (HR) were measured during one hour after the injury. A marked decrease in MAP and HR was observed immediately after injury, followed by an abrupt increase in MAP. These changes were observed between 3 and 9 min and the basal values were recovered after 20 min. Fall in the MAP and HR and increase in MAP induced by SCI were abolished by atropine. The interruption of the parasympathetic outflow by vagotomy also significantly diminished the fall and increase in MAP and the fall in HR. Likewise, pre-treatment with nitric oxide synthase inhibitor N(G)-nitro-L-arginine methyl ester (L-NAME) completely abolished the effects produced by SCI. These data suggest that after SCI the decrement in MAP and HR was probably due to acetylcholine release from parasympathetic fibers and NO from endothelial source probably by a cholinergic stimulation. Additionally, the MAP increase observed was probably due to a reflex compensatory vasoconstriction. |
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Authors:
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G Bravo; R Rojas-Martínez; F Larios; E Hong; G Castañeda-Hernández; G Rojas; G Guízar-Sahagún |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Life sciences Volume: 68 ISSN: 0024-3205 ISO Abbreviation: Life Sci. Publication Date: 2001 Feb |
Date Detail:
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Created Date: 2001-03-16 Completed Date: 2001-03-29 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0375521 Medline TA: Life Sci Country: England |
Other Details:
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Languages: eng Pagination: 1527-34 Citation Subset: IM |
Affiliation:
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Depto. Farmacobiología, CINVESTAV, IPN, México DF, México. gbravof@prodigy.net.mx |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acetylcholine
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metabolism Animals Atropine / pharmacology Blood Pressure / physiology* Endothelium, Vascular / metabolism Heart / innervation Heart Rate / physiology* Male Models, Animal NG-Nitroarginine Methyl Ester / pharmacology Nitric Oxide Synthase / antagonists & inhibitors Parasympathetic Nervous System / metabolism Rats Rats, Wistar Spinal Cord Injuries / metabolism, physiopathology* Vagotomy |
| Chemical | |
Reg. No./Substance:
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50903-99-6/NG-Nitroarginine Methyl Ester; 51-55-8/Atropine; 51-84-3/Acetylcholine; EC 1.14.13.39/Nitric Oxide Synthase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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